Inventors:
Terri H. Finkel - Wynnewood PA, US
Jiyi Yin - Swarthmore PA, US
Assignee:
The Children's Hospital of Philadelphia - Philadelphia PA
International Classification:
C07H 21/04, C12N 15/11, A61K 35/00
US Classification:
536 235, 536 231, 435235, 435 6, 435455, 435 2
Abstract:
This invention provides cellular gene products which have anti-apoptotic activity in HIV-1 infected cells. Other pro-apoptotic genes and methods of use thereof are also disclosed. The compositions of the invention may be used to advantage to develop novel therapeutic agents for the treatment of HIV infection. The compositions of the invention may also be used to advantage to develop novel therapeutic agents for the treatment of disorders associated with inordinate cellular apoptosis.