Inventors:
Grover C. Bagby - Portland OR, US
Tanja Pejovic - Portland OR, US
Laura Hays - Portland OR, US
Susan Olson - Portland OR, US
International Classification:
C12Q 1/68, C12Q 1/02, C40B 30/04, G01N 33/574
US Classification:
435 6, 435 29, 506 9, 435 723
Abstract:
Methods are provided for determining diagnosing ovarian and breast cancer in a subject, including diagnosing the predisposition of a subject's risk of developing breast or ovarian cancer. The methods include selecting a subject, for example a subject with one or more risk factors for developing ovarian cancer or breast cancer, and detecting a decrease in the activity of the Fanconi anemia (FA) non-nuclear core (NNC) component in the subject. Such a decrease is indicative of a predisposition to ovarian cancer and/or breast cancer in the subject. These methods can be used to monitor the response of a subject to agents designed to prevent breast and ovarian cancer, for example an anti-neoplastic agent. Methods also are provided for identifying agents of use in preventing breast and ovarian cancer.