Inventors:
Lynne Canne Bannen - Lucerne CA, US
Diva Sze-Ming Chan - Oakland CA, US
Jeff Chen - San Francisco CA, US
Lisa Esther Dalrymple - San Francisco CA, US
Timothy Patrick Forsyth - Hayward CA, US
Tai Phat Huynh - Oakland CA, US
Vasu Jammalamadaka - Pleasanton CA, US
Richard George Khoury - San Mateo CA, US
James William Leahy - San Leandro CA, US
Morrison B. Mac - San Francisco CA, US
Grace Mann - Brisbane CA, US
Larry W. Mann - Richland MI, US
John M. Nuss - Danville CA, US
Jason Jevious Parks - Sacramento CA, US
Yong Wang - Foster City CA, US
Wei Xu - Danville CA, US
Assignee:
Exelixis, Inc. - South San Francisco CA
International Classification:
A61K 31/4709, A61K 31/517, C07D 215/233, C07D 401/12, A61K 31/47, C07D 239/94, C07D 417/12, C07D 401/10, C07D 413/12, A61K 31/5377, C07D 215/46, C07D 417/14, A61K 31/501, A61K 31/496, A61K 31/513, C12N 9/99, C12Q 1/48, C12Q 1/66, A61P 35/00, A61P 29/00, A61P 37/00, A61P 37/06, A61P 25/00, A61P 17/06, A61P 9/00, A61P 9/10, A61P 1/00, A61P 19/02, A61P 27/02, C07D 403/10
US Classification:
51421018, 544287, 5142662, 546153, 514312, 544293, 5142664, 544128, 5142352, 546160, 514313, 544238, 51425204, 544363, 51425307, 544316, 514274, 51421021, 544119, 5142345, 435184, 435 15, 435 8, 435 71
Abstract:
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.