Inventors:
David G. Hangauer - East Amherst NY, US
Fengzhi Li - Buffalo NY, US
Taher Hegab - Fresno CA, US
Xiang Ling - Snyder NY, US
International Classification:
C07D 403/04
Abstract:
Disclosed are compounds having the formula:wherein Zis an alkylene moiety; Q is a carboxylic acid derivative; and Rand Rare the same or different and are selected from the group consisting of alkyl, aryl, alkylcarbonyl, arylcarbonyl, hydroxycarbonyl, and alkoxycarbonyl or Rand R, taken together with the nitrogen atom to which they are bound, form a ring. Also disclosed are compounds having the formula:wherein Zis an alkylene moiety; Q is a carboxylic acid derivative; and Ris selected from the group consisting of alkyl and aryl. The compounds can be used to modulate cell proliferation and/or apoptosis, for example, in the treatment of cancers and other proliferative diseases, disorders, and conditions.