Inventors:
Vincent Santora - Thousand Oaks CA, US
Benny Askew - Newbury Park CA, US
Arup Ghose - Thousand Oaks CA, US
Andrew Hague - Camarillo CA, US
Tae Kim - Thousand Oaks CA, US
Ellen Laber - Ventura CA, US
Aiwen Li - Newbury Park CA, US
Brian Lian - Bloomington IN, US
Gang Liu - Oak Park CA, US
Mark Norman - Thousand Oaks CA, US
Leon Smith - Sommerset NJ, US
Andrew Tasker - Simi Valley CA, US
Christopher Tegley - Thousand Oaks CA, US
Kevin Yang - San Gabriel CA, US
International Classification:
A61K031/501, C07D239/02, A61K031/535, A61K031/505
US Classification:
514/227500, 514/237800, 514/241000, 514/242000, 514/247000, 514/252010, 514/256000, 514/252100, 514/252130, 514/315000, 514/326000, 514/649000, 514/432000, 514/459000, 544/059000, 544/162000, 544/180000, 544/182000, 544/224000, 544/238000, 544/242000, 544/333000, 544/359000, 546/229000
Abstract:
Selected novel urea compounds are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stoke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.