SYLVAN GERALD FRANK
Pharmacy in Columbus, OH
License number
Pennsylvania RP026032L
Category
Pharmacy
Type
Pharmacist
Address
Address
2
Columbus, OH 43212
Pennsylvania
Pennsylvania
Personal information
See more information about SYLVAN GERALD FRANK at radaris.comName
Address
Phone
1910 Wyandotte Ave, Upper Arlington, OH 43212
Columbus, OH
Professional information
Associate Dean/Professor At The Ohio State University
Position:
Associate Dean/Professor at The Ohio State University
Location:
Columbus, Ohio Area
Industry:
Pharmaceuticals
Work:
The Ohio State University
-
Associate Dean/Professor
Method Of Preparing Solid Dispersions
US Patent:
2003010, Jun 5, 2003
Filed:
Oct 1, 2002
Appl. No.:
10/220935
Inventors:
Arne Brodin - Sodertalje, SE
Sylvan Frank - Columbus OH, US
Chao Ye - Lake Bluff IL, US
Sylvan Frank - Columbus OH, US
Chao Ye - Lake Bluff IL, US
International Classification:
A61K031/24, A61K009/14, B29B009/00
US Classification:
424/486000, 264/005000, 514/536000
Abstract:
The present invention is directed to improved methods for producing solid dispersions, especially pharmaceutical dispersions. These methods involve the dissolution of one or more insoluble or relatively insoluble substances, preferably pharmaceutically active substances, and/or one or more water-soluble substances, preferably carriers, in supercritical fluids and the subsequent removal of solvent by rapid expansion. These methods offer a number of advantages over traditional preparation methods and form formulations with highly desirable dissolution properties, especially for pharmaceuticals.
Small Particle Formation
US Patent:
4606939, Aug 19, 1986
Filed:
Jun 15, 1984
Appl. No.:
6/621133
Inventors:
Sylvan G. Frank - Columbus OH
Arne F. Brodin - Sodertalje, SE
Chih-Ming J. Chen - East Syracuse NY
Ratnesh Shrivastava - Columbus OH
Arne F. Brodin - Sodertalje, SE
Chih-Ming J. Chen - East Syracuse NY
Ratnesh Shrivastava - Columbus OH
Assignee:
The Ohio State University Research Foundation - Columbus OH
International Classification:
B01J 1302
US Classification:
4272133
Abstract:
The present invention is concerned with the simultaneous formation and encapsulation of small particles of organic compounds whose solubility in water is greater at a first pH than at a second pH by concurrently precipitating said organic compounds as small particles and forming a coacervate of an anionic (or cationic) surfactant and an amphoteric surfactant. The process is preferably used to prepare a readily soluble encapsulated pharmaceutically active compound.
Small Particle Formation And Encapsulation
US Patent:
4606940, Aug 19, 1986
Filed:
Dec 21, 1984
Appl. No.:
6/684457
Inventors:
Sylvan G. Frank - Columbus OH
Arne F. Brodin - Sodertalje, SE
Shulin Ding - Columbus OH
Arne F. Brodin - Sodertalje, SE
Shulin Ding - Columbus OH
Assignee:
The Ohio State University Research Foundation - Columbus OH
International Classification:
A61K 950, B01J 1302
US Classification:
42721332
Abstract:
Process for the formation and the simultaneous encapsulation of small particles of a compound from solution which comprises:
(a) dissolving said compound in a first solvent;
(b) preparing a solution of encapsulating material and an electrolyte in a second solvent which is miscible with the first solvent and in which the compound to be encapsulated is more or less insoluble, in an amount which is effective, but present in an amount just insufficient to cause coacervation of the encapsulating material without interacting with it;
(c) mixing the solutions from step (a) and (b) while stirring to cause the concurrent precipitation of the compound as small particles and formation of a coacervate of the encapsulating material; and
(d) gelling the encapsulating material.
Precipitation Of One Or More Active Compounds In Situ
US Patent:
5916583, Jun 29, 1999
Filed:
Nov 21, 1995
Appl. No.:
8/563880
Inventors:
Fredrik Broberg - Trosa, SE
Arne Brodin - Sodertalje, SE
Lisbet Rydhag - Enhorna, SE
Sylvan G. Frank - Columbus OH
Arne Brodin - Sodertalje, SE
Lisbet Rydhag - Enhorna, SE
Sylvan G. Frank - Columbus OH
Assignee:
Astra Aktiebolag - Sodertalje
International Classification:
A61K 908
US Classification:
424426
Abstract:
The present invention relates to an injectable solution for administration of one or more active compounds. According to the invention the active compound, which is in its neutral form, is dissolved in a biologically acceptable solvent whereby the active compound by administration precipitates, forming a solid phase of the solution in situ. Thus, said solution, which is easy to sterilize, is acting like a suspension when injected.
Small Particule Formation And Encapsulation
US Patent:
4608278, Aug 26, 1986
Filed:
Jun 15, 1984
Appl. No.:
6/621132
Inventors:
Sylvan G. Frank - Columbus OH
Arne F. Brodin - Sodertalje, SE
Chih-Ming J. Chen - East Syracuse NY
Arne F. Brodin - Sodertalje, SE
Chih-Ming J. Chen - East Syracuse NY
Assignee:
The Ohio State University Research Foundation - Columbus OH
International Classification:
B01J 1302
US Classification:
42721335
Abstract:
The present invention is concerned with the simultaneous formation and encapsulation of small particles from aqueous solutions of compounds whose solubility is greater at a first pH than at a second pH. The process is preferably used to prepare a readily soluble encapsulated pharmaceutically active compound.
Small Particle Formation
US Patent:
5780062, Jul 14, 1998
Filed:
Nov 27, 1995
Appl. No.:
8/553460
Inventors:
Sylvan Frank - Columbus OH
Jan-Erik Lofroth - Molndal, SE
Levon Bostanian - Metairie LA
Jan-Erik Lofroth - Molndal, SE
Levon Bostanian - Metairie LA
Assignee:
The Ohio State University Research Foundation - Coloumbus OH
International Classification:
A61K 916
US Classification:
424501
Abstract:
The present invention is concerned with the formation of small particles of organic compounds by precipitating said organic compounds in an aqueous medium containing polymer/amphiphile complexes. The process is preferably used to prepare a readily soluble pharmaceutically active compound.