Inventors:
James G. Phillips - Bay Village OH
Clark E. Tedford - South Russell OH
Nishith C. Chaturvedi - Gujarat, IN
Syed M. Ali - Solon OH
Assignee:
Gliatech, Inc. - Cleveland OH
International Classification:
A61K 31417, A61K 314174, C07D23364
Abstract:
The present invention provides, in its principal aspect, compounds of the general formula: ##STR1## when A is --NHCO--, --N(CH. sub. 3)--CO--, --NHCH. sub. 2 --, --N(CH. sub. 3)--CH. sub. 2 --, --CH. dbd. CH--, --COCH. sub. 2 --, CH. sub. 2 CH. sub. 2 --, --CH(OH)CH. sub. 2 -- or --C. tbd. C--;
X can be H, CH. sub. 3, NH. sub. 2, NH(CH. sub. 3),N(CH. sub. 3). sub. 2, OH, OCH. sub. 3, SH,
R. sub. 2 is hydrogen or a methyl or ethyl group;
R. sub. 3 is hydrogen or a methyl or ethyl group;
n is 0, 1, 2, 3, 4, 5 or 6;
R. sub. 1 is selected from the group consisting of (a) alkyl; (b) C. sub. 3 to C. sub. 8 cycloalkyl; (c) phenyl or substituted phenyl; (d) heteroocyclic; and (f) decahydronaphthalene or octahydroindane; and
When R. sub. 1 and X taken together denote a 5, 6 or 6, 6 saturated bicyclic ring structure, X can be NH, O, S, SO. sub. 2,
When X is constrained in a 5, 6 or 6, 6, saturated bicyclic ring structure, then for example, when X. dbd. NH, R. sub.