SYDNEY MOLLY EVANS
Veterinary in Delaware
License number
Pennsylvania BV004448L
Category
Veterinary Medicine
Type
Veterinarian
Address
Address
2
Delaware
Swarthmore, PA 19081
Swarthmore, PA 19081
Professional information
Detection Of Hypoxia
US Patent:
6855828, Feb 15, 2005
Filed:
Aug 25, 2000
Appl. No.:
09/648306
Inventors:
Cameron J. Koch - Aldan PA, US
Alexander V. Kachur - Upper Darby PA, US
Sydney M. Evans - Swarthmore PA, US
Ian R. Baird - Vancouver, CA
Kirsten A. Skov - Vancouver, CA
Brian R. James - Vancouver, CA
Alexander V. Kachur - Upper Darby PA, US
Sydney M. Evans - Swarthmore PA, US
Ian R. Baird - Vancouver, CA
Kirsten A. Skov - Vancouver, CA
Brian R. James - Vancouver, CA
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C07D233/91
US Classification:
5483275, 435 11, 435 121, 436 57, 436 98, 436124, 436905
Abstract:
Nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive byproducts, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.
Detection Of Hypoxia
US Patent:
2005002, Feb 3, 2005
Filed:
Aug 27, 2004
Appl. No.:
10/927696
Inventors:
Cameron Koch - Aldan PA, US
Alexander Kachur - Upper Darby PA, US
Sydney Evans - Swarthmore PA, US
Ian Baird - Vancouver, CA
Kirsten Skov - Vancouver, CA
William Dolbier - Gainesville FL, US
Brian James - Vancouver, CA
Alexander Kachur - Upper Darby PA, US
Sydney Evans - Swarthmore PA, US
Ian Baird - Vancouver, CA
Kirsten Skov - Vancouver, CA
William Dolbier - Gainesville FL, US
Brian James - Vancouver, CA
International Classification:
C07D277/38, A61K031/426
US Classification:
514370000, 548190000
Abstract:
Novel nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive byproducts, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.
Nitroaromatic Compounds For The Detection Of Hypoxia
US Patent:
6252087, Jun 26, 2001
Filed:
Jul 28, 1998
Appl. No.:
9/123300
Inventors:
Cameron J. Koch - Aldan PA
Alexander V. Kachur - Upper Darby PA
Sydney M. Evans - Swarthmore PA
Ian R. Baird - Vancouver, CA
Kirsten A. Skov - Vancouver, CA
William R. Dolbier - Gainesville FL
Brian R. James - Vancouver, CA
Alexander V. Kachur - Upper Darby PA
Sydney M. Evans - Swarthmore PA
Ian R. Baird - Vancouver, CA
Kirsten A. Skov - Vancouver, CA
William R. Dolbier - Gainesville FL
Brian R. James - Vancouver, CA
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C07D23391, G07K 1618
US Classification:
5483275
Abstract:
Nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive byproducts, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.
Methods For Diagnosis And Treatment Of Tumors In Humans
US Patent:
6300136, Oct 9, 2001
Filed:
Sep 3, 1998
Appl. No.:
9/146401
Inventors:
Cameron J. Koch - Aldan PA
Sydney M. Evans - Swarthmore PA
Sydney M. Evans - Swarthmore PA
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
G01N 3348, G01N 3350
US Classification:
436 64
Abstract:
The invention relates to the discovery that the concentration of free cysteine in mammalian tumor tissue is elevated compared with the concentration of free cysteine in non-tumor tissue of the same origin. Elevated levels of free cysteine is, in turn, correlated with resistance of tumors to antitumor therapy such as chemotherapy and radiation therapy. Therefore, the invention further relates to methods of detecting the presence of tumors in mammalian tissues, assessing the resistance of tumors to antitumor therapies as it relates to free cysteine concentration, and to the identification of compounds which affect free cysteine concentration in mammalian tissues.