SYDNEY DAVID FINKELSTEIN
Medical Practice in Pittsburgh, PA
License number
Pennsylvania MD039582L
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Pittsburgh, PA 15222
Personal information
See more information about SYDNEY DAVID FINKELSTEIN at radaris.comName
Address
Phone
311 Marberry Dr, Pittsburgh, PA 15215
534 Guyasuta Rd, Pittsburgh, PA 15215
Professional information
Dynamic Genomic Deletion Expansion And Formulation Of Molecular Marker Panels For Integrated Molecular Pathology Diagnosis And Characterization Of Tissue, Cellular Fluid, And Pure Fluid Specimens
US Patent:
2006008, Apr 27, 2006
Filed:
Oct 24, 2005
Appl. No.:
11/256152
Inventors:
Sydney Finkelstein - Pittsburgh PA, US
Patricia Swalsky - Pittsburgh PA, US
Patricia Swalsky - Pittsburgh PA, US
International Classification:
C12Q 1/68, C12P 19/34
US Classification:
435006000, 435091200
Abstract:
Provided are materials, methods, platforms, and kits for diagnosing, prognosing, and/or determining the biological aggressiveness of a tumor (malignant and non-malignant) based in part on the temporal profile of genomic deletion expansion of the tumor. Also provided are methods of determining marker panels for different diseases and/or tissues and markers identified by these methods.
Sydney David Finkelstein, Pittsburgh PA
Specialties:
Pathologist
Address:
816 Middle St, Pittsburgh, PA 15212
Education:
McGill University, Faculty of Medicine - Doctor of Medicine
Board certifications:
American Board of Pathology Certification in Anatomic Pathology (Pathology), American Board of Pathology Sub-certificate in Neuropathology (Pathology)
Dr. Sydney D Finkelstein, Pittsburgh PA - MD (Doctor of Medicine)
Specialties:
Neuropathology
Address:
816 Middle St SUITE 2ND, Pittsburgh 15212
(412) 231-3600 (Phone), (412) 231-2207 (Fax)
(412) 231-3600 (Phone), (412) 231-2207 (Fax)
Certifications:
Anatomic Pathology, 1984, Neuropathology, 1984
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
McGill University / Faculty of Medicine
McMaster U Tchg Hosp
U Toronto Tchg Hosp
McGill University / Faculty of Medicine
McMaster U Tchg Hosp
U Toronto Tchg Hosp
Topographic Genotyping
US Patent:
6340563, Jan 22, 2002
Filed:
Jun 24, 1996
Appl. No.:
08/667493
Inventors:
Sydney David Finkelstein - Aspinwall PA 15215
Patricia Anne Finkelstein - Aspinwall PA 15215
Patricia Anne Finkelstein - Aspinwall PA 15215
International Classification:
C12Q 168
US Classification:
435 6
Abstract:
A method for topographic genotyping is described. The method comprises the steps of placing a biological specimen having DNA of a patient under a microscope. Then there is the step of inspecting the biological specimen microscopically with the microscope. Next there is the step of choosing a microscope size target on the biological specimen based on its histopathologic characteristics. Next there is the step of separating the target from the specimen. Then there is the step of obtaining DNA sequences from the target so the DNA sequences can be amplified. Next there is the step of amplifying the DNA sequences. Then there is the step of detecting mutations in the DNA sequences. More specifically, the method comprises the steps of separating a section from a specimen of fixative treated tissue. Then there is the step of obtaining DNA sequences from the section. Next there is the step of amplifying the DNA sequences by cycling them in a PCR machine, with each cycle heating them to a temperature no greater than 99° C.
Topographic Genotyping For Determining The Diagnosis, Malignant Potential, And Biologic Behavior Of Pancreatic Cysts And Related Conditions
US Patent:
2006008, Apr 27, 2006
Filed:
Oct 24, 2005
Appl. No.:
11/255978
Inventors:
Sydney Finkelstein - Pittsburgh PA, US
Patricia Swalsky - Pittsburgh PA, US
Patricia Swalsky - Pittsburgh PA, US
International Classification:
C12Q 1/68, G06F 19/00
US Classification:
435006000, 702020000
Abstract:
The application relates to a method of a predicting the presence of invasive pancreatic cancer or high grade dysplasia, pre-cancerous pancreatic states and non-neoplastic conditions comprising detailed molecular analysis incorporating DNA quality and quantity, K-ras mutational analysis and a broad spectrum of tumor suppressor gene linked microsatellite LOH. Methods of diagnosing, determining prognosis of and determining a course of treatment for pancreatic cancer or high grade dysplasia, pre-cancerous pancreatic states and non-neoplastic conditions are also provided.
Molecular Analysis Of Cellular Fluid And Liquid Cytology Specimens For Clinical Diagnosis, Characterization, And Integration With Microscopic Pathology Evaluation
US Patent:
2006014, Jun 29, 2006
Filed:
Oct 24, 2005
Appl. No.:
11/256150
Inventors:
Sydney Finkelstein - Pittsburgh PA, US
Patricia Swalsky - Pittsburgh PA, US
Patricia Swalsky - Pittsburgh PA, US
International Classification:
C12Q 1/68
US Classification:
435006000
Abstract:
The application relates to methods, materials, kits, and devices for characterizing fluid specimens of any type or source that may or may not contain cells. The methods, materials, kits, and devices can be used for analyzing fluid obtained from various organs or near a purported tumor site, such as via breast ductal lavage or aspiration of a pancreatic cyst. The methods, materials, kits, and devices generate molecular information that can be used in conjunction with clinical, imaging, and microscopic pathology evaluation to provide a superior pathology diagnosis for clinical and research.
Topographic Genotyping
US Patent:
2006015, Jul 13, 2006
Filed:
Nov 30, 2005
Appl. No.:
11/289624
Inventors:
Sydney Finkelstein - Aspinwall PA, US
Patricia Finkelstein - Aspinwall PA, US
Patricia Finkelstein - Aspinwall PA, US
International Classification:
C12Q 1/68
US Classification:
435006000
Abstract:
The present invention pertains to a method for topographic genotyping. The method comprises the steps of placing a biological specimen having DNA of a patient under a microscope. Then there is the step of inspecting the biological specimen microscopically with the microscope. Next there is the step of choosing a microscope size target on the biological specimen based on its histopathologic characteristics. Next there is the step of separating the target from the specimen. Then there is the step of obtaining DNA sequences from the target so the DNA sequences can be amplified. Next there is the step of amplifying the DNA sequences. Then there is the step of detecting mutations in the DNA sequences. The present invention pertains to a method for topographic genotyping. The method comprises the steps of separating a section from a specimen of fixative treated tissue. Then there is the step of obtaining DNA sequences from the section. Next there is the step of amplifying the DNA sequences by cyphaling them in a PCR machine, with each cycle heating them to a temperature no greater than 99° C., and then back to a temperature of 55° C. in 5 minutes. Next there is the step of detecting mutations in the DNA sequences. Preferably, the separating step includes the step of cutting one to three 2-6 micron thick histeologic sections from the specimen.
Enhanced Amplifiability Of Minute Fixative-Treated Tissue Samples, Minute Stained Cytology Samples, And Other Minute Sources Of Dna
US Patent:
2006011, Jun 1, 2006
Filed:
Oct 24, 2005
Appl. No.:
11/255980
Inventors:
Sydney Finkelstein - Pittsburgh PA, US
Patricia Swalsky - Pittsburgh PA, US
Patricia Swalsky - Pittsburgh PA, US
International Classification:
C12Q 1/68, C12P 19/34, C12N 1/08
US Classification:
435006000, 435091200, 435270000
Abstract:
The specification provides materials and methods for enhancing the amplifiability of nucleic acids that are present in minute amounts. Preferably, the materials and methods are utilized in combination with pathology techniques to amplify nucleic acids obtained from fixative and/or stained tissue or cell samples. The amplified nucleic acids can then be utilized for rendering a diagnosis or prognosis to the subject from which the tissue or cellular sample was obtained.
Pcr Method And Related Apparatus
US Patent:
2006020, Sep 14, 2006
Filed:
May 12, 2006
Appl. No.:
11/433722
Inventors:
Tony Godfrey - Pittsburgh PA, US
James Luketich - Pittsburgh PA, US
Siva Raja - Pittsburgh PA, US
Lori Kelly - Jeanette PA, US
Sydney Finkelstein - Pittsburgh PA, US
James Luketich - Pittsburgh PA, US
Siva Raja - Pittsburgh PA, US
Lori Kelly - Jeanette PA, US
Sydney Finkelstein - Pittsburgh PA, US
International Classification:
C12Q 1/68, C12P 19/34
US Classification:
435006000, 435091200
Abstract:
A method for balancing multiplexed PCR methods is provided. In the method, two or more sequential temporal PCR stages are used to effectively separate two or more PCR reactions in a single tube as an alternative to primer limiting to modulate the relative rate of production of a first amplicon by a first primer set and a second amplicon by a second primer set during the first and second amplification stages. Also provided are rapid RT-PCR methods that find particular use in intraoperative diagnoses and prognoses, for instance in diagnosing malignant esophageal adenocarcenoma by determining expression levels of carcinoembryonic antigen (CEA) in sentinel lymph nodes.
Methods Of Differentiating Between Non-Genotoxin And Genotoxin-Associated Tumors
US Patent:
2012015, Jun 21, 2012
Filed:
Dec 20, 2011
Appl. No.:
13/331966
Inventors:
Sydney D. FINKELSTEIN - Pittsburgh PA, US
Eric Matthew Gayle Ellsworth - Pittsburgh PA, US
Eric Matthew Gayle Ellsworth - Pittsburgh PA, US
International Classification:
C12Q 1/68
US Classification:
435 611
Abstract:
Embodiments of the present disclosure are directed to methods of differentiation of non-genotoxin associated versus genotoxin-associated tumors.