Inventors:
Shao Chu - Encinitas CA, US
Larry Alegria - San Diego CA, US
Steven Bender - Oceanside CA, US
Suzanne Benedict - San Diego CA, US
Allen Borchardt - San Diego CA, US
Robert Kania - San Diego CA, US
Mitchell Nambu - San Diego CA, US
Sepehr Sarshar - Cardiff By The Sea CA, US
Dilip Bhumralkar - San Diego CA, US
Zhengwei Peng - San Diego CA, US
Michelle Yang - San Diego CA, US
Assignee:
Agouron Pharmaceuticals, Inc.
International Classification:
C07D419/02, A61K031/427
Abstract:
Diaminothiazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction in order to modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.