Inventors:
David E. Heinrichs - London, CA
Suzanne Dale - Rochester NY, US
International Classification:
A61K 39/40, C12N 1/20, A61K 31/708, C07K 14/31, C12N 9/10, C12N 9/88, A61P 31/04, A01N 37/18, A01N 43/90, A01P 1/00
US Classification:
4241581, 4352521, 514 44 A, 4241641, 530350, 435193, 435232
Abstract:
Isolation of an iron regulated, nme-gene operon (designated sbn) from (RN6390), responsible for the biosynthesis of staphylobactm, a novel siderophore Methods for treating or preventing a disease or condition caused by infection, as well as methods for identifying agents that inhibit the biosynthesis of staphylobactm or inhibit the expression of genes in said sbn operon are further disclosed.