Inventors:
Susan D. Wilson - Silver Spring MD, US
Wendy White - Germantown MD, US
JoAnn Suzich - Washington Grove MD, US
Brian Mullikin - Mt. Airy MD, US
Assignee:
MedImmune, Inc. - Gaithersburg MD
International Classification:
A61K039/00
US Classification:
4241921, 4242041, 435 691, 435 697, 530300
Abstract:
Disclosed are chimeric HPV L1 proteins and virus like particles comprising the same which are capable of generating high titer neutralizing antibody responses against at least two HPV types. The disclosed chimeric HPV L1 proteins and VLPs are useful as therapeutic and prophylactic reagents, as well as reagents for diagnosing papillomavirus infection.