SUSAN M MANZI
Medical Practice in Wexford, PA
License number
Pennsylvania MD041866E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Wexford, PA 15090
Personal information
See more information about SUSAN M MANZI at radaris.comName
Address
Phone
2486 Matterhorn Dr, Wexford, PA 15090
3471 Flavian St, Pittsburgh, PA 15219
3471 5Th St, Pittsburgh, PA 15213
300 Halket St, Pittsburgh, PA 15213
2486 Matterhorn Dr, Wexford, PA 15090
Professional information
Assessing Risk Of Cerebrovascular Thrombosis By Measuring C4D On Platelets
US Patent:
2007020, Aug 30, 2007
Filed:
Sep 14, 2006
Appl. No.:
11/521643
Inventors:
Joseph Ahearn - Sewickley PA, US
Susan Manzi - Wexford PA, US
Amy Kao - Allison Park PA, US
Susan Manzi - Wexford PA, US
Amy Kao - Allison Park PA, US
Assignee:
University of Pittsburgh - Pittsburgh PA
International Classification:
G01N 33/567, G06F 19/00
US Classification:
435007210, 702021000
Abstract:
This invention provides for a convenient, economical, and sensitive test for assessing the risk of a person suffering from a thrombotic stroke. More specifically, it has been determined that persons at risk for cerebrovascular thrombosis have an elevated deposition of C4d on their platelets.
Assessing Risk Of Cerebrovascular Thrombosis By Measuring C4D
US Patent:
2008013, Jun 5, 2008
Filed:
Nov 13, 2007
Appl. No.:
11/939188
Inventors:
Joseph M. Ahearn - Sewickley PA, US
Susan M. Manzi - Wexford PA, US
Amy Kao - Pittsburgh PA, US
Susan M. Manzi - Wexford PA, US
Amy Kao - Pittsburgh PA, US
International Classification:
G01N 33/567, G06F 19/00
US Classification:
435 721, 702 21
Abstract:
The present invention provides methods for the convenient, economical and sensitive assessment of the risk of whether a person will suffer from a thrombotic stroke. The present invention also provides methods for diagnosing or monitoring cerebrovascular thrombosis in a person as well as assessing the degree of severity of a cerebrovascular thrombosis in a person. More specifically, it has been determined that persons at risk of, or has been afflicted with, a cerebrovascular thrombosis have an elevated deposition of C4on their platelets.
Method For Diagnosis And Monitoring Of Disease Activity And Response To Treatment In Systemic Lupus Erythematosus (Sle) And Other Autoimmune Diseases
US Patent:
2010023, Sep 16, 2010
Filed:
Oct 16, 2009
Appl. No.:
12/581057
Inventors:
Joseph M. Ahearn - Sewickley PA, US
Edward L. Erickson - Pipersville PA, US
Douglas M. Hawkins - Edina MN, US
Susan M. Manzi - Wexford PA, US
Thomas Mercolino - Chapel Hill NC, US
Edward L. Erickson - Pipersville PA, US
Douglas M. Hawkins - Edina MN, US
Susan M. Manzi - Wexford PA, US
Thomas Mercolino - Chapel Hill NC, US
Assignee:
CYPRESS BIOSCIENCE, INC. - San Diego CA
UNIVERSITY OF PITTSBURGH - Pittsburgh PA
UNIVERSITY OF PITTSBURGH - Pittsburgh PA
International Classification:
C12Q 1/02
US Classification:
435 29
Abstract:
The present invention provides methods of diagnosing and monitoring systemic lupus erythematosus and drug-induced lupus erythematosus by measuring cell-based complement activation products in a subject's blood. In particular, the invention describes a diagnostic method employing the measurement of multiple complement activation products, such as C3and C4, on the surfaces of red blood cells, white blood cells, and platelets. Kits and automated systems for performing the methods of the invention are also disclosed.
Diagnosis And Monitoring Of Systemic Lupus Erythematosus And Of Scleroderma
US Patent:
7390631, Jun 24, 2008
Filed:
Sep 9, 2002
Appl. No.:
10/489219
Inventors:
Joseph M. Ahearn - Sewickley PA, US
Susan M. Manzi - Wexford PA, US
Susan M. Manzi - Wexford PA, US
Assignee:
University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
G01N 33/00
US Classification:
435 725, 435 71, 435 721, 435372, 4352872, 435967, 435973, 436507, 436520, 436546, 436548, 436 10, 436 63, 436172, 436811, 436821, 422 61
Abstract:
Methods for diagnosing and monitoring systemic lupus erythematosus (SLE) or scleroderma by determining, in a blood sample from the individual being diagnosed or monitored, complement component C4d deposited on surfaces of red blood cells in the sample, and optionally also determining complement receptor CR1 deposited on the red blood cell surfaces. For diagnosis this is compared with the quantity of C4d (and optionally CR1) present on red blood cells of normal individuals. For monitoring it is compared with a value in a sample or samples previously obtained from the individual patient. The comparison may be made with individual values for C4d and CR1 and/or with a ratio of the two found in normal individuals.
Diagnosing And Monitoring Inflammatory Diseases By Measuring Complement Components On White Blood Cells
US Patent:
2009029, Dec 3, 2009
Filed:
Jul 29, 2009
Appl. No.:
12/511956
Inventors:
Joseph M. Ahearn - Sewickley PA, US
Susan M. Manzi - Wexford PA, US
Chau-Ching Liu - Pittsburgh PA, US
Susan M. Manzi - Wexford PA, US
Chau-Ching Liu - Pittsburgh PA, US
Assignee:
University of Pittsburgh - Pittsburgh PA
International Classification:
G01N 33/566
US Classification:
436501
Abstract:
The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells.
Diagnosing And Monitoring Inflammatory Diseases By Measuring Complement Components On White Blood Cells
US Patent:
2011027, Nov 10, 2011
Filed:
Jul 19, 2011
Appl. No.:
13/186380
Inventors:
Joseph M. Ahearn - Sewickley PA, US
Susan M. Manzi - Wexford PA, US
Chau-Ching Liu - Pittsburgh PA, US
Susan M. Manzi - Wexford PA, US
Chau-Ching Liu - Pittsburgh PA, US
Assignee:
University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
G01N 33/53, C12Q 1/70, G01N 33/577
US Classification:
435 5, 435 724
Abstract:
The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells.
Diagnosing And Monitoring Inflammatory Diseases By Measuring Complement Components On White Blood Cells
US Patent:
7585640, Sep 8, 2009
Filed:
May 11, 2005
Appl. No.:
10/545052
Inventors:
Joseph M. Ahearn - Sewickley PA, US
Susan M. Manzi - Wexford PA, US
Chau-Ching Liu - Pittsburgh PA, US
Susan M. Manzi - Wexford PA, US
Chau-Ching Liu - Pittsburgh PA, US
Assignee:
University of Pittsburgh - Pittsburgh PA
International Classification:
G01N 33/00
US Classification:
435 724, 435 71, 435 721, 435372, 4352872, 435967, 435973, 436507, 436520, 436546, 436548, 436 10, 436 63, 436172, 436811, 436821
Abstract:
The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells.
Identification And Monitoring Of Systemic Lupus Erythematosus
US Patent:
2012012, May 17, 2012
Filed:
Jan 25, 2012
Appl. No.:
13/358428
Inventors:
Joseph M. Ahearn - Sewickley PA, US
Susan M. Manzi - Wexford PA, US
Jeannine Navratil - Pittsburgh PA, US
Susan M. Manzi - Wexford PA, US
Jeannine Navratil - Pittsburgh PA, US
International Classification:
G01N 21/64, G01N 33/566
US Classification:
436501
Abstract:
A method for identifying or monitoring SLE in an individual is provided. The method includes quantitating complement component C4on the surfaces of platelets and comparing the amounts of C4to reference levels of C4on platelets of individuals without SLE and/or on platelets of the individual obtained at a different time. Kits for use in the above-described methods are provided along with computer readable media tangibly embodying executable instructions to perform the methods.
Identification And Monitoring Of Systemic Lupus Erythematosus
US Patent:
7588905, Sep 15, 2009
Filed:
Apr 16, 2004
Appl. No.:
10/552177
Inventors:
Joseph M. Ahearn - Sewickley PA, US
Susan M. Manzi - Wexford PA, US
Jeannine Navratil - Pittsburgh PA, US
Susan M. Manzi - Wexford PA, US
Jeannine Navratil - Pittsburgh PA, US
Assignee:
University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA
International Classification:
G01N 33/00
US Classification:
435 724, 435 71, 435 721, 435372, 4352872, 435967, 435973, 436507, 436520, 436546, 436548, 436 10, 436 63, 436172, 436811, 436821
Abstract:
A method for identifying or monitoring SLE in an individual is provided. The method includes quantitating complement component C4d on the surfaces of platelets and comparing the amounts of C4d to reference levels of C4d on platelets of individuals without SLE and/or on platelets of the individual obtained at a different time. Kits for use in the above-described methods are provided along with computer readable media tangibly embodying executable instructions to perform the methods.
Identification Of Apolipoprotein H Mutations And Their Diagnostic Uses
US Patent:
6203980, Mar 20, 2001
Filed:
Feb 2, 1998
Appl. No.:
9/016390
Inventors:
M. Ilyas Kamboh - Pittsburgh PA
Dharambir K. Sanghera - Pittsburgh PA
Susan Manzi - Wexford PA
Dharambir K. Sanghera - Pittsburgh PA
Susan Manzi - Wexford PA
Assignee:
University of Pittsburgh - Pittsburgh PA
International Classification:
C12Q 168, C12P 1934, C07H 2104
US Classification:
435 6
Abstract:
Structural mutations in the fifth domain of apolipoprotein H have been identified which affect phospholipid binding and which predict protection from systemic lupus erythematosis which can be used in genetic analysis.