Inventors:
Samuel J. Danishefsky - Englewood NJ
Philip O. Livingston - New York NY
In Jong Kim - New York NY
Howard Scher - Tenafly NJ
Susan Slovin - New York NY
Assignee:
Sloan-Kettering Institute for Cancer Research - New York NY
International Classification:
A01N11304
US Classification:
514 23, 514 42, 514 54, 514 62, 4241841, 4242771
Abstract:
The present invention provides a method of synthesizing a compound having the structure: as well as other related glycoconjugates useful as vaccines for inducing antibodies to epithelial cancer cells in an adjuvant therapy therefore, and in a method for preventing recurrence of epithelial cancer. The present invention also provides a vaccine comprising an amount of the compound described above effective to prevent the recurrence of cancer in a subject.