Inventors:
Bruce Horwitz - Lexington MA, US
James Fox - Harvard MA, US
Susan Erdman - Hopkinton MA, US
Anne Davidson - Ardsley NY, US
Assignee:
The Brigham and Women's Hospital, Inc. - Boston MA
International Classification:
A61K 39/395, A61K 38/20
Abstract:
The present invention is directed to methods for the treatment of adenocarcinomas that are characterized by the overexpression of a particular oncogene, Pim-1. The procedure involves administering a therapeutically effective amount of interleukin-10 that has been coupled to a carrier that increases its circulating plasma half-life.