SURYA N VANGAPANDU
Pharmacy at Marietta Pkwy, Marietta, GA
License number
Georgia RPH023975
Category
Pharmacy
Type
Pharmacist
Address
Address
2
23 S Marietta Pkwy SW, Marietta, GA 30064
11980 Fox Rd, Alpharetta, GA 30005
11980 Fox Rd, Alpharetta, GA 30005
Phone
(770) 420-8932
(770) 442-3337
(770) 442-3337
Personal information
See more information about SURYA N VANGAPANDU at radaris.comName
Address
Phone
11980 Fox Rd, Alpharetta, GA 30005
11980 Fox Rd, Alpharetta, GA 30005
Professional information
9-Aminonoscapine And Its Use In Treating Cancers, Including Drug-Resistant Cancers
US Patent:
2011029, Dec 1, 2011
Filed:
Sep 4, 2009
Appl. No.:
13/062481
Inventors:
Harish C. Joshi - Decatur GA, US
Ritu Aneja - Lilburn GA, US
Surya N. Vangapandu - Alpharetta GA, US
Ritu Aneja - Lilburn GA, US
Surya N. Vangapandu - Alpharetta GA, US
Assignee:
EMORY UNIVERSITY - Atlanta GA
International Classification:
A61K 31/4741, A61P 35/00, A61P 35/02, C07D 491/056
US Classification:
514291, 546 90
Abstract:
9-aminonoscapine, prodrugs thereof, and pharmaceutically acceptable salts thereof, are disclosed. Pharmaceutical compositions including 9-aminonoscapine, and methods of preparation and use thereof are disclosed. 9-aminonoscapine is a noscapine analog that can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers, by binding tubulin and inducing apoptosis selectively in tumor cells (ovarian and T-cell lymphoma) resistant to paclitaxel, vinblastine and teniposide. 9-aminonoscapine can perturb the progression of cell cycle by mitotic arrest, followed by apoptotic cell death associated with increased caspase-3 activation and appearance of TUNEL-positive cells. Thus, 9-aminonoscapine is a novel therapeutic agents for a variety of cancers, including ovarian and T-cell lymphoma cancers, even those that have become drug-resistant to currently available chemotherapeutic drugs.
9-Aminonoscapine And Its Use In Treating Cancers, Including Drug-Resistant Cancers
US Patent:
2013015, Jun 13, 2013
Filed:
Feb 8, 2013
Appl. No.:
13/762753
Inventors:
Emory University - Atlanta GA, US
Ritu Aneja - Lilburn GA, US
Surya N. Vangapandu - Alpharetta GA, US
Ritu Aneja - Lilburn GA, US
Surya N. Vangapandu - Alpharetta GA, US
Assignee:
EMORY UNIVERSITY - Atlanta GA
International Classification:
C07D 491/056
US Classification:
514150, 514291
Abstract:
9-aminonoscapine, prodrugs thereof, and pharmaceutically acceptable salts thereof, are disclosed. Pharmaceutical compositions including 9-aminonoscapine, and methods of preparation and use thereof are disclosed. 9-aminonoscapine is a noscapine analog that can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers, by binding tubulin and inducing apoptosis selectively in tumor cells (ovarian and T-cell lymphoma) resistant to paclitaxel, vinblastine and teniposide. 9-aminonoscapine can perturb the progression of cell cycle by mitotic arrest, followed by apoptotic cell death associated with increased caspase-3 activation and appearance of TUNEL-positive cells. Thus, 9-aminonoscapine is a novel therapeutic agents for a variety of cancers, including ovarian and T-cell lymphoma cancers, even those that have become drug-resistant to currently available chemotherapeutic drugs.
Noscapine Analogs And Their Use In Treating Cancers
US Patent:
2013022, Aug 29, 2013
Filed:
Jun 5, 2012
Appl. No.:
13/488621
Inventors:
Harish C. Joshi - Decatur GA, US
Ritu Aneja - Lilburn GA, US
Surya N. Vangapandu - Alpharetta GA, US
Ritu Aneja - Lilburn GA, US
Surya N. Vangapandu - Alpharetta GA, US
Assignee:
Emory University - Atlanta GA
International Classification:
A61K 31/4741, A61K 45/06
US Classification:
424623, 514291, 424649, 514285, 514 34, 514 27, 514 49, 514110, 514 193, 514283, 514 48, 514 111, 514 43, 514274, 514249, 514275
Abstract:
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are noscapine analogs. The compounds and compositions can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers. While the antitussive plant alkaloid, noscapine, binds tubulin, displays anticancer activity, and has a safe pharmacological profile in humans, structure-function analyses pointed to a proton at position 9 of the isoquinoline ring that can be modified without compromising tubulin binding activity. Noscapine analogs with various functional moieties at position 9 on the isoquinoline ring kill human cancer cells resistant to other anti-microtubule agents, such as vincas and taxanes.
Conjugates Of Noscapine And Folic Acid And Their Use In Treating Cancer
US Patent:
8426398, Apr 23, 2013
Filed:
Jan 8, 2010
Appl. No.:
13/142908
Inventors:
Harish C. Joshi - Decatur GA, US
Surya N. Vangapandu - Alpharetta GA, US
Ritu Aneja - Lilburn GA, US
Surya N. Vangapandu - Alpharetta GA, US
Ritu Aneja - Lilburn GA, US
Assignee:
Emory University - Atlanta GA
International Classification:
A01N 43/00, A01N 43/42, A61K 31/33, C07D 475/00
US Classification:
514183, 514291, 544261
Abstract:
The present invention is directed to compounds which are conjugates of two non-toxic natural products, noscapine (and various noscapine analogs) and folic acid (and various folic acid analogs), where the folic acid is conjugated to noscapine or the noscapine analog at the 9-position on the isoquinoline ring on the noscapine framework. Pharmaceutical compositions including the compounds, and methods of treating various tumors using the compounds and compositions, are also disclosed. The conjugates are particularly useful for treating cancers which overexpress the Folate Receptor α (FRa) receptor.