Inventors:
Sunil Badve - Indianapolis IN, US
Lang Li - Carmel IN, US
George Sledge - Indianapolis IN, US
Renata Duchnowaska - Warsaw, PL
Jacek Jassem - Gdansk, PL
Patricia Steeg - Laurel MD, US
Assignee:
INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION - Indianapolis IN
International Classification:
C40B 30/04, G01N 33/574, C07K 16/22, C07K 16/32, C07K 16/40, C07K 16/18, C12Q 1/68, C07H 21/00
US Classification:
506 9, 435 611, 435 71, 536 2431, 5303877, 5303897, 5303892
Abstract:
Aspects of the invention include methods for identifying patients with HER2+ cancers that are at a heightened risk for developing brain metastasis within three years of having been diagnosed with HER2+ cancer. Some embodiments are methods that include the steps of contacting at least a portion of the tumor tissue from patients with probes that interact with the products of a set of thirteen genes that are expressed in these patients at markedly higher levels than in similarly situated patients that are not a heightened risk for developing brain metastasis within this three year window. In some embodiments the tissue samples are assayed from the presence of RNA indicative of the expression of member of a set of 13 genes identified as being differentially expressed in patients with and without a heightened risk for developing brain metastasis.