Sung Wan Kim
Hearing Aid Provider in Salt Lake City, UT

7320890, Jan 22, 2008

Apr 5, 2005

11/099999

Ram I. Mahato - Memphis TN, US
Anurag Maheshwari - Salt Lake City UT, US
Sung Wan Kim - Salt Lake City UT, US

University of Utah Research Foundation - Salt Lake City UT

C12N 15/85

4353201, 536 235, 536 241

Amphiphilic lipopeptide compositions for gene delivery are disclosed. An illustrative amphiphilic lipopeptide composition includes a human protamine 2 peptide conjugated to a hydrophobic moiety. Illustrative hydrophobic moieties include sterols, bile acids, and fatty acids. The amphiphilic lipopeptide composition is mixed with a nucleic acid such that the nucleic acid binds to the peptide portion of the lipopeptide. This mixture is placed in contact with mammalian cells to effect transfection of the cells with the nucleic acid. A method of making such amphiphilic lipopeptides is also described.

2013012, May 16, 2013

Jun 14, 2012

13/523334

David A. Bull - Salt Lake City UT, US
Rafe C. Connors - Keswick VA, US
Harold M. Erickson - Cora WY, US
James Yockman - West Jordan UT, US
Sung Wan Kim - Salt Lake City UT, US

UNIVERSITY OF UTAH FOUNDATION - Salt Lake City UT

A61K 35/34, C12N 5/071

600439, 604522

A biologic ventricular assist device that also has the capability to capture, grow, and administer stem cells to regenerate and restore damaged myocardium in the heart. The device works in conjunction with a traditional ventricular assist device and possesses an additional external path or tube that is in-line with the path of the ventricular assist device. The external path allows for the administration of stem cells, genes, genetically modified cells or other therapeutic biologic or pharmacologic agents, as well as leading to a stem cell collecting accessory that captures circulating stem cells. The stem cell collecting accessory is also associated with a chamber for culturing the captured stem cells. The cultured stem cells can be delivered back to the heart by an electro-mechanical or ultrasound/echocardiographic delivery system that runs through the external path back into the ventricular assist device and allows for the delivery of the stem cells, or other therapeutic biologic or pharmacologic agents, directly into the internal chambers of the heart. Administering the stem cells, genes, genetically modified cells or other therapeutic biologic or pharmacologic agents, either alone or in combination, to the heart allows the myocardium to regenerate and repair itself even while the heart is attached to the ventricular assist device, ultimately allowing the heart to regenerate, recover and allow the VAD to be removed.

7740877, Jun 22, 2010

Apr 6, 2007

11/784528

Sung Wan Kim - Salt Lake City UT, US
Seongbong Jo - Salt Lake City UT, US
Jin Kim - Salt Lake City UT, US

University of Utah Research Foundation - Salt Lake City UT

A61F 2/02, C08G 63/08

424426, 528354

A thermogelling, aliphatically modified polymer for use in drug delivery is described. Illustrative embodiments include poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone) hexanoate and poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone) laurate. Another illustrative embodiment includes a composition having a thermogelling amount of an aliphatically modified poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone) and an effective amount of a drug. The thermogelling polymers are made by bonding an aliphatic group to poly(lactic-co-ε-caprolactone)-poly(ethylene glycol)-poly(lactic-co-ε-caprolactone). A method of use includes injecting a warm-blooded individual with a thermogelling amount of the aliphatically modified polymer and a drug.

5226902, Jul 13, 1993

Jul 30, 1991

7/737675

You H. Bae - Salt Lake City UT
Sung W. Kim - Salt Lake City UT
Lev I. Valuev - Moscow, SU

University of Utah - Salt Lake City UT

A61K 922

6048921

A device for the dispensing of a biologically active material into the surrounding environment is disclosed which consists of at least one wall enclosing a compartment which contains a swollen stimuli sensitive hydrogel in which the biologically active material is entrained in solution. The hydrogel deswells or shrinks in response to contact by external physical or chemical stimuli releasing the biologically active material into the portion of the compartment previously occupied by the swollen hydrogel. The wall enclosing the compartment is rigid and contains means allowing the passage of the biologically active material from the compartment to the surrounding environment and also for transmitting the external stimuli to the swollen hydrogel in said compartment. The wall may contain orifices or be permeable to the active material and external stimuli depending upon the drug and the stimuli to be used. The hydrogel reversibly deswells, shrinks or contracts in response to stimuli, such as temperature, pH, ionic strength, glucose concentration or metabolites in the body and then reswells and reentrains active material not diffused from the compartment when the stimuli is removed.

2009014, Jun 4, 2009

Nov 7, 2008

12/266980

James W. Yockman - Salt Lake City UT, US
Jonathan Brumbach - Salt Lake City UT, US
Lane V. Christensen - Bridgewater NJ, US
Sung Wan Kim - Salt Lake City UT, US

UNIVERSITY OF UTAH RESEARCH FOUNDATION - SALT LAKE CITY UT

C12N 15/87, C12N 15/00, C08G 63/91, C08G 71/04

435455, 4353201, 525 541, 525187

Improved poly(amido ethylenimine) copolymers for gene delivery are disclosed. One illustrative embodiment includes polyethylene glycol (PEG) covalently bonded to a branched poly(triethyenetetramine/cystamine bisacrylamide) copolymer (poly(TETA/CBA)). The polyethylene glycol can be linear or branched. Another illustrative embodiment includes an RGD peptide covalently bonded to the poly(TETA/CBA)-PEG conjugate. Still another illustrative embodiment includes a method of using these compositions for transfecting a cell with a nucleic acid.

6217912, Apr 17, 2001

Jul 13, 1999

9/352473

Jong Sang Park - Seoul, KR
Young Hun Choi - Seoul, KR
Sung Wan Kim - Salt Lake City UT

Expression Genetics, Inc. - Salt Lake City UT

A61K 4714, A61K 4800, C12N 1585, C12N 1500

424501

Poly[. alpha. -(4-aminobutyl)-L-glycolic acid] (PAGA) is disclosed as a biodegradable composition suitable for delivering a gene into a cell. Methods of making and using PAGA are also disclosed.

7183263, Feb 27, 2007

Jul 17, 2003

10/623020

Darin Y. Furgeson - Salt Lake City UT, US
Sung Wan Kim - Salt Lake City UT, US

University of Utah Research Foundation - Salt Lake City UT

A61K 31/7052, A61K 31/56, C07J 9/00

514 44, 514171, 552544

Linear polyethylenimine was modified with sterols, such as cholesterol, in three different geometries: linear shaped (L), T-shaped (T), and a combined linear- and T-shaped (LT), to result in linear polyethylenimine-sterol conjugates. These conjugates were mixed with nucleic acids to form complexes for delivery of the nucleic acids into cells. Mammalian cells transfected with these complexes showed protein expression levels higher than linear polyethylenimine alone, and twice that of branched polyethylenimine, but without any significant loss in cell viability. Methods of making these compositions and methods of using them for gene delivery are also described.

7740880, Jun 22, 2010

Mar 3, 2006

11/367228

Won Jong Kim - Salt Lake City UT, US
Sung Wan Kim - Salt Lake City UT, US

University of Utah Research Foundation - Salt Lake City UT

A61K 9/127, A61K 31/70, A01N 43/04

424450, 514 44

A carrier for delivering small interfering RNA (siRNA) into cells includes a cholesterol residue covalently bonded to oligoarginine. Mixing the siRNA with the carrier produces a complex-containing composition. Contacting a cell with the complex-containing composition results in delivery of the siRNA into the cell. Delivery of an siRNA targeted to vascular endothelial growth factor is a treatment for cancer. Methods of making the carrier and complex are also disclosed.

8153154, Apr 10, 2012

Feb 12, 2009

12/370515

Sung Wan Kim - Salt Lake City UT, US
Tae-il Kim - Salt Lake City UT, US

University of Utah - Salt Lake City UT

A61K 9/14, C07H 21/04

424486, 536 231, 536 245

An arginine-grafted bioreducible poly(disulfide amine) (“ABP”) as a reagent for efficient and nontoxic gene delivery is described. ABP forms positively charged nano-particles of less than 200 nm with plasmid DNA. ABP is biodegraded under reducing conditions, such as the cytoplasm. ABP exhibits much higher transfection efficiency than polyethyleneimine in mammalian cells and exhibits no cytotoxicity.

2009013, May 21, 2009

Nov 7, 2008

12/267015

Sung Wan Kim - Salt Lake City UT, US
Mei Ou - Salt Lake City UT, US

UNIVERSITY OF UTAH RESEARCH FOUNDATION - Salt Lake City UT

C12N 15/00, C07C 233/00, C07H 21/00, C12N 15/63, C07H 21/02

4353201, 564153, 564159, 536 221, 536 231, 435455

Poly(disulfide amine)s, methods of making, and methods of use are described. Illustrative embodiments of the poly(disulfide amine)s include poly(CBA-DAE), poly(CBA-DAB), and poly(CBA-DAH). These compositions are made by Michael addition between N,N′-cystaminebisacrylamide and N-Boc-protected diamine monomers, followed by N-Boc deprotection. Complexes are formed by mixing the poly(disulfide amine)s with nucleic acid. Delivery of the nucleic acid into cells is carried out by contacting the cells with the nucleic acid/poly(disulfide amine) complexes.