Sun A Kim
Nursing in Salt Lake City, UT

5262055, Nov 16, 1993

Oct 19, 1992

7/962879

You H. Bae - Salt Lake City UT
Sun W. Kim - Salt Lake City UT

The University of Utah - Salt Lake City UT

B01D 6100, B01D 6308, B01D 6906

210645

An artificial pancreas system which minimizes the volume of the artificial pancreas by not encapsulating each islet is taught wherein the islets are separated and held within a polymeric matrix which is soluble in an aqueous solution below body temperature but insoluble in aqueous solutions at or above body temperature. The polymer-islet mixture is contained in a pouch having access means such as entry and exit ports. The solubility makes it possible to replace the contents of the pouch by solubilizing the matrix simply by lowering the temperature below the LCST. The pouch is constructed of a biocompatible material permeable to insulin and other substances of similar or lesser molecular weight but is impermeable to cellular and humoral components of the body immune system. The islet-polymer matrix can be functionalized to stimulate insulin secretion from the islets using insulinotropic agents such as sulfonylurea. Also, polymeric microparticles which release bioactive agents which either promote vascularization at the pouch membrane outer surface or inhibit macrophage activity can be added to the polymer matrix.

4693019, Sep 15, 1987

Mar 3, 1986

6/835345

Sun K. Kim - Salt Lake City UT

A43B 110, A43B 500

36 73

This invention is a sports shoe protector having a sole and a means for securing the sole to a sports shoe having spikes. The sole includes at least one U-shaped shoulder extending from a peripheral portion of the base of the sole to provide peripheral support to the shoe and to provide an open area for receiving shoe spikes. An inner support extending from the base and positioned within the mouth of the U-shaped shoulder can be used to provide additional support and to form, in combination with the U-shaped shoulder, an open channel area for receiving shoe spikes.