Inventors:
Rangaramanujam M. Kannan - Detroit MI, US
Sujatha Kannan - Detroit MI, US
Roberto Romero - Gross Points MI, US
Raghavendra S. Navath - Somerset NJ, US
Hui Dai - Rochester Hills MI, US
Anupa R. Menjoge - Hayward CA, US
Assignee:
NATIONAL INSTITUTES OF HEALTH - Rockville MD
WAYNE STATE UNIVERSITY - Detroit MI
International Classification:
A61K 47/48, A61K 49/00, A61P 29/00, C08G 69/48
US Classification:
424 91, 525432, 525420, 424 7817
Abstract:
A nanodevice composition including N-acetyl cysteine linked to a dendrimer, such as a PAMAM dendrimer or a multiarm PEG polymer, is provided. Also provided is a nanodevice for targeted delivery of a compound to a location in need of treatment. The nanodevice includes a PAMAM dendrimer or multiarm PEG polymer, linked to the compound via a disulfide bond. There is provided a nanodevice composition for localizing and delivering therapeutically active agents, the nanodevice includes a PAMAM dendrimer or multiarm PEG polymer and at least one therapeutically active agent attached to the PAMAM dendrimer or multiarm PEG polymer. A method of site-specific delivery of a therapeutically active agent, by attaching a therapeutically active agent to a PAMAM dendrimer or multiarm PEG polymer using a disulfide bond, administering the PAMAM dendrimer or multiarm PEG polymer to a patient in need of treatment, localizing the dendrimer or multiarm PEG polymer to a site in need of treatment, and releasing the therapeutically active agent at the site in need of treatment.