Inventors:
Carl H. June - Merion Station PA, US
Craig B. Thompson - Philadelphia PA, US
Suil Kim - San Francisco CA, US
Assignee:
The Regents of the University of Michigan - Ann Arbor MI
The United States of America as represented by the Secretary of the Navy - Washington DC
International Classification:
C12N 15/63, C12N 5/12, C12N 5/00, C12Q 1/68, A61K 48/00
US Classification:
435455, 435 6, 435325, 435375, 424 9321
Abstract:
A method for transfecting T cells with a nucleic acid molecule comprising a gene such that the gene is expressed in the T cells is described. The T cells are stimulated and proliferating prior to introduction of the nucleic acid molecule.