SUHAIL MOHAMMAD ALI
Medical Practice in Swatara, PA
License number
Michigan 4301059456
Issued Date
Sep 16, 1993
Expiration Date
Jan 31, 2006
Category
Medicine
Type
Medical Doctor
Address
Address
Swatara, PA 17033
Professional information
Assays For Cancer Patient Monitoring Based On Levels Of Epidermal Growth Factor Receptor (Egfr) Extracellular Domain (Ecd) Analyte, Alone Or In Combination With Other Analytes, In Body Fluid Samples
US Patent:
2003021, Nov 27, 2003
Filed:
Feb 27, 2003
Appl. No.:
10/375371
Inventors:
Walter Carney - North Andover MA, US
Peter Hamer - Reading MA, US
Allan Lipton - Hershey PA, US
Kim Leitzel - Hummelstown PA, US
Suhail Ali - Hershey PA, US
Peter Hamer - Reading MA, US
Allan Lipton - Hershey PA, US
Kim Leitzel - Hummelstown PA, US
Suhail Ali - Hershey PA, US
International Classification:
G01N033/574
US Classification:
435/007230
Abstract:
The present invention describes clinically and medically important methods of monitoring the outcome of a cancer patient who is suffering from disease or who is undergoing treatment or therapy for his or her disease. More specifically, the invention provides a method of monitoring the progression of disease or cancer treatment effectiveness in a cancer patient by measuring the level of the extracellular domain (ECD) of the epidermal growth factor receptor (EGFR) in a sample taken from the cancer patient, preferably, before treatment, at the start of treatment, and at various time intervals during treatment, wherein a decrease in the level of the ECD of the EGFR in the cancer patient compared with the level of the ECD of the EGFR in normal control individuals serves as an indicator of cancer advancement or progression and/or a lack of treatment effectiveness for the patient. As another aspect of determining disease outcome and survival, the invention further provides assessing both EGFR and HER-2/neu levels, in combination, in a patient sample. A finding of decreased levels of EGFR concomitantly with elevated or increased levels of HER-2/neu relative to control levels indicates poor outcome and short time to progression.