Inventors:
Sudhir V. Shah - Little Rock AR, US
Alexei G. Basnakian - Little Rock AR, US
Yousri M. Barri - Richardson TX, US
Assignee:
Board of Trustees of the University of Arkansas - Little Rock AR
The United States of America as represented by the Department of Veterans Affairs - Washington DC
International Classification:
A61K 49/00
US Classification:
424 92, 424 934, 435 2, 435 3, 435967, 436 15, 436 16, 436 55, 436 71, 436175, 436177, 436178, 436506, 436811
Abstract:
The present invention provides a method of determining whether an individual is at risk for atherosclerosis, comprising the step of measuring the level of cLDL and/or autoantibody to cLDL in a sample obtained from this individual. The invention further discloses a method of reducing carbamylation in an individual with a monomeric amino acid or other enzymatic or non-enzymatic inhibitors of carbamylation. The instant invention also provides a method to decrease the level of cLDL by direct elimination of cLDL from the blood or plasma of an individual. The invention also provides a method of treating or preventing atherosclerosis in an individual by inhibiting aggregation and/or deposition of cLDL in the individual.