Inventors:
Michael McVoy - Richmond VA, US
Stuart Adler - Richmond VA, US
Xiaohong Cui - Quinton VA, US
Assignee:
Virginia Commonwealth University - Richmond VA
International Classification:
C07K 14/045, A61K 39/245, C07K 16/18, C07K 16/08, A61K 39/395, C07K 14/02, A61K 39/385
US Classification:
4241341, 530300, 530324, 530350, 4242301, 4241861, 4241921, 4241991, 4242001, 4241591, 5303873, 4352351
Abstract:
Combination peptides, polypeptides and proteins that elicit high titer neutralizing antibodies against cytomegalovirus (CMV) are provided. The combination peptides, polypeptides and proteins encompass epitopes located within the UL130 and UL131 components of the gH/gL/UL128-131 protein complex, in particular, epitopes located within amino acid residues 27-46 of UL130 and amino acid residues 90-106 of UL131. The combination peptides, polypeptides and proteins, and the nucleic acids encoding them, may be used in vaccines, and as diagnostic and research tools.