Inventors:
John A. Zebala - Sammamish WA, US
Dean Y. Maeda - Seattle WA, US
Joel R. Morgan - Kent WA, US
Stuart J. Kahn - Seattle WA, US
International Classification:
A61K 31/519, C07D 475/08, A61P 19/02, A61P 17/00, A61P 1/00, A61P 35/02, A61P 35/00
Abstract:
There is disclosed a pharmaceutical composition comprising racemic aminopterin or pharmaceutically acceptable salts thereof. There is further disclosed a method to treat a disorder in a patient comprising administering a therapeutically effective amount of racemic aminopterin or pharmaceutically acceptable salts of racemic aminopterin. More particularly, there is disclosed a method for treating disorders modulated by at least dihydrofolate reductase activity, such as cancers and inflammatory disorders, wherein the method comprises administering to a patient in need thereof a therapeutically effective amount of racemic aminopterin or a pharmaceutically acceptable salt thereof.