Inventors:
Roger G. Harrison - Norman OK, US
J. Thomas Pento - Norman OK, US
Stuart E. Lind - Greenwood Village CO, US
International Classification:
A61K 38/51, A61P 35/00, C12N 5/06
Abstract:
A conjugate is disclosed herein, wherein the conjugate includes a ligand having the ability to specifically and stably bind to an external receptor or binding site on a tumor vasculature endothelial cell, wherein the external receptor or binding site is specific for tumor vasculature endothelial cells. The conjugate also includes an anticancer agent that is selectively toxic to cancer cells operatively attached to the ligand. The anticancer agent may be L-methioninase. Pharmaceutical compositions comprising the conjugate are also disclosed, as well as methods of treating a cancer tumor or cancer cells with a therapeutically effective amount of the conjugate.