Inventors:
Daniel W. Goodman - Riverside CT, US
Michael R. Hanley - Corte Madera CA, US
Stuart L. Bursten - Napa CA, US
Charles N. Serhan - Needham MA, US
Assignee:
Brigham and Women's Hospital, Inc. - Boston MA
Resolvyx Pharmaceuticals, Inc. - Bedford MA
International Classification:
A61K 31/22, A61K 31/20, A61K 31/16, C07C 231/00, C07C 59/00
US Classification:
514549, 514560, 514625, 554 61, 554219
Abstract:
The present invention is directed to compounds that are analogues of lipid mediators derived from a fish oil-derived fatty acid, eicosapentaenoic acid [C20:5 ω-3; EPA], but with a longer tissue half-life and enhanced bioactivity. These analogues may be used to treat inflammatory, angioproliferative, cardiovascular, thrombophlebotic, vascular, ocular, dermatologic, neurodegenerative, pulmonary, endocrine, reproductive, rheumatologic and gastrointestinal diseases.