STUART B LEVY, MD
Osteopathic Medicine at Washington St, Boston, MA
License number
Massachusetts 33134
Category
Osteopathic Medicine
Type
Hematology
Address
Address
750 Washington St, Boston, MA 02111
Phone
(617) 636-5000
(617) 636-7105
(617) 636-6204 (Fax)
(617) 636-7105
(617) 636-6204 (Fax)
Personal information
See more information about STUART B LEVY at radaris.comName
Address
Phone
109 North Rd, Chelmsford, MA 01824
Arlington, MA
Vineyard Haven, MA
Organization information
See more information about STUART B LEVY at bizstanding.comCenter For Adaptation GNTCS - Stuart B Levy MD
136 Harrison Ave, Boston, MA 02111
Categories:
Hematology Physicians & Surgeons
Phone:
(617) 636-3651 (Phone)
Professional information
See more information about STUART B LEVY at trustoria.com
Principal, Sgl Chemistry Consulting; Chemical And Pharmaceutical Development Professional
Principal, Sgl Chemistry Consulting; Chemical And Pharmaceutical Development Professional
Position:
Career Consultant at American Chemical Society, Principal at SGL Chemistry Consulting
Location:
Greater Boston Area
Industry:
Pharmaceuticals
Work:
American Chemical Society
since May 2011
-
Career Consultant
SGL Chemistry Consulting
- Arlington, MA, USA since May 2010
-
Principal
PPD Dermatology (Formerly Magen Biosciences)
- Waltham, MA Mar 2008 - May 2010
-
Director, Chemistry
Elixir Pharmaceuticals
- Cambridge, MA May 2005 - Feb 2008
-
Director, Pharmaceutics and Manufacturing
EPIX Pharmaceuticals
Oct 2001 - May 2005
-
Senior Staff Scientist, Chemistry R+D
Ricerca, LLC
Mar 2000 - Sep 2001
-
Senior Research Chemist / Project Leader
SUGEN
Dec 1998 - Mar 2000
-
Process Chemist
SERES Laboratories
1995 - 1998
-
Scientist
Education:
University of California, San Diego - School of Medicine 1992 - 1995
Post-Doc, Organic chemistry, medicinal chemistry University of Illinois at Chicago 1987 - 1992
PhD, Chemistry
Post-Doc, Organic chemistry, medicinal chemistry University of Illinois at Chicago 1987 - 1992
PhD, Chemistry
Skills:
Drug Discovery, Chemistry, Medicinal Chemistry, Technology Transfer, Pharmaceutical Industry, Drug Development, FDA, R&D, Clinical Development, Biotechnology, Formulation, Process Simulation, Cell, IND, Lifesciences, Pharmaceutics, Analytical Chemistry, Validation, HPLC, Oncology, Organic Chemistry, Quality Assurance
7-And 9-Carbamate, Urea, Thiourea, Thiocarbamate, And Heteroaryl-Amino Substituted Tetracycline Compounds
7-And 9-Carbamate, Urea, Thiourea, Thiocarbamate, And Heteroaryl-Amino Substituted Tetracycline Compounds
US Patent:
6818634, Nov 16, 2004
Filed:
Mar 30, 2001
Appl. No.:
09/823884
Inventors:
Mark L. Nelson - Wellesley MA
Stuart B. Levy - Boston MA
Roger Frechette - Reading MA
Todd E. Bowser - Charlton MA
Mohamed Y. Ismail - Bedford MA
Stuart B. Levy - Boston MA
Roger Frechette - Reading MA
Todd E. Bowser - Charlton MA
Mohamed Y. Ismail - Bedford MA
Assignee:
Paratek Pharmaceuticals, Inc. - Boston MA
Trustees of Tufts College - Medford MA
Trustees of Tufts College - Medford MA
International Classification:
A61K 3165
US Classification:
514152, 548194
Abstract:
Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates useful for synthesizing other tetracycline compounds are also included.
Reducing Tetracycline Resistance In Living Cells
Reducing Tetracycline Resistance In Living Cells
US Patent:
7732429, Jun 8, 2010
Filed:
Aug 19, 2008
Appl. No.:
12/194362
Inventors:
Stuart B. Levy - Boston MA, US
Assignee:
Trustees of Tufts College - Medford MA
International Classification:
A61K 31/65
US Classification:
514154
Abstract:
The present invention provides an improved methodology by which therapeutically to overcome resistance to tetracycline in living cells including bacteria, parasites, fungi, and rickettsiae. The methodology employs a blocking agent such as C5 ester derivatives, or 6-deoxy 13-(substituted mercapto) derivatives of tetracycline, in combination with other tetracycline-type antibiotics as a synergistic combination of compositions to be administered simultaneously, sequentially or concurrently. In another embodiment, certain novel compositions are provided which may be administered alone against, for example, a sensitive or resistant strain of gram positive bacteria such as and. The concomitantly administered compositions effectively overcome the tetracycline resistant mechanisms present such that the cell is effectively converted from a tetracycline-resistant state to a tetracycline-sensitive state.
Transcription Factor Modulating Compounds And Methods Of Use Thereof
Transcription Factor Modulating Compounds And Methods Of Use Thereof
US Patent:
2011023, Sep 22, 2011
Filed:
Aug 6, 2009
Appl. No.:
12/536887
Inventors:
Stuart B. LEVY - Boston MA, US
Michael N. ALEKSHUN - Wakefield MA, US
Brent L. PODLOGAR - Flemington NJ, US
Kwasi OHEMENG - Norwood MA, US
Atul K. VERMA - Mansfield MA, US
Tadeusz WARCHOL - Northborough MA, US
Beena BHATIA - Mansfield MA, US
Todd BOWSER - Charlton MA, US
Mark GRIER - Cambridge MA, US
Michael N. ALEKSHUN - Wakefield MA, US
Brent L. PODLOGAR - Flemington NJ, US
Kwasi OHEMENG - Norwood MA, US
Atul K. VERMA - Mansfield MA, US
Tadeusz WARCHOL - Northborough MA, US
Beena BHATIA - Mansfield MA, US
Todd BOWSER - Charlton MA, US
Mark GRIER - Cambridge MA, US
Assignee:
Paratek Pharmaceuticals, Inc. - Boston MA
International Classification:
A61K 31/4184, A61K 31/4439, A01N 43/52, C07D 235/22, C07D 401/04, A01P 1/00, A61P 31/00, A61P 31/04, C12N 1/36
US Classification:
514338, 514395, 5483101, 5462734, 435245
Abstract:
Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
Crystals Of Marr Polypeptides, Regulators Of Multiple Antibiotic Resistance
Crystals Of Marr Polypeptides, Regulators Of Multiple Antibiotic Resistance
US Patent:
2007015, Jul 5, 2007
Filed:
Feb 16, 2007
Appl. No.:
11/707404
Inventors:
Michael Alekshun - Wakefield MA, US
Stuart Levy - Boston MA, US
James Head - Newton MA, US
Barbara Seaton - Newton MA, US
Stuart Levy - Boston MA, US
James Head - Newton MA, US
Barbara Seaton - Newton MA, US
Assignee:
Trustees of Tufts College - Medford MA
BOSTON UNIVERSITY - Boston MA
BOSTON UNIVERSITY - Boston MA
International Classification:
C07K 14/705, G06F 19/00
US Classification:
530350000, 702019000
Abstract:
The crystal structure of the product, crystals of the MarR protein, a regulator of multiple antibiotic resistance in , and methods of crystallization of the MarR protein are described.
Tetracycline Activity Enhancement
Tetracycline Activity Enhancement
US Patent:
4806529, Feb 21, 1989
Filed:
Nov 18, 1982
Appl. No.:
6/442688
Inventors:
Stuart B. Levy - Boston MA
Assignee:
Trustees of Tufts College, Tufts University - Medford MA
International Classification:
A61K 3165, A61K 3500
US Classification:
514154
Abstract:
Methods and products for overcoming bacterial resistance to tetracycline-type antibiotics by inhibiting the plasmid-mediated active efflux system for tetracycline in the resistant bacterial cell by administering with tetracycline efflux system blocking agents, thereby increasing the sensitivity of the resistant cell to tetracycline type antibiotics.
Identification And Isolation Of New Genes Of A Bacterial Multiple Antibiotic Resistance Regulon
Identification And Isolation Of New Genes Of A Bacterial Multiple Antibiotic Resistance Regulon
US Patent:
5766924, Jun 16, 1998
Filed:
Jul 21, 1997
Appl. No.:
8/897357
Inventors:
Stuart B. Levy - Boston MA
Assignee:
Trustees of Tufts College - Medford MA
International Classification:
C12N 120, C12N 100, C07H 2104
US Classification:
4352523
Abstract:
Methods of identifying loci and isolating genes of a bacterial multiple antibiotic resistance regulon are disclosed. In addition, isolated nucleic acids of three new genes, designated mlr1, mlr2 and mlr3, of the bacterial multiple antibiotic resistance regulon are disclosed and enabled. Transformed bacterial cells with altered expression of these new genes and methods for their use in evaluating potential antimicrobial or antibiotic compounds are also provided. Purified proteins encoded by these genes and antibodies to those proteins are also provided.
Pharmaceutically Active Compounds And Methods Of Use Thereof
Pharmaceutically Active Compounds And Methods Of Use Thereof
US Patent:
2004015, Aug 5, 2004
Filed:
Jan 20, 2004
Appl. No.:
10/762081
Inventors:
Stuart Levy - Boston MA, US
Mark Nelson - Norfolk MA, US
Mark Nelson - Norfolk MA, US
Assignee:
Trustees of Tufts College - Medford MA
International Classification:
A61K031/65
US Classification:
514/152000, 552/204000, 546/285000, 548/528000
Abstract:
The invention includes new substituted tetracycline-type compounds that exhibit significant antibacterial activity, including against both gram-positive and gram-negative bacteria. It has been found that compounds of the invention are highly active against both gram positive and gram negative tetracycline sensitive and tetracycline resistant bacteria.
Novel Blr Molecules Affecting Antibiotic Susceptibility
Novel Blr Molecules Affecting Antibiotic Susceptibility
US Patent:
2002005, May 2, 2002
Filed:
Apr 6, 2001
Appl. No.:
09/828456
Inventors:
Stuart Levy - Boston MA, US
Rebecca Wong - Port Coquitlam, CA
Laura McMurry - Cambridge MA, US
Rebecca Wong - Port Coquitlam, CA
Laura McMurry - Cambridge MA, US
International Classification:
C12Q001/68, G01N033/554, G01N033/569, C07H021/04, C12N009/00, C12N001/21
US Classification:
435/006000, 435/007320, 435/183000, 435/252300, 536/023200
Abstract:
A novel 358 base pair sequence encoding a membrane protein that affects susceptibility to antibiotics that affect peptidoglycan synthesis in microbes is described. BLR nucleic acid and polypeptide molecules are provided. In addition, screening assays to identify agents that modulate BLR activity are described.
Tetracycline Compounds For Treatment Of Related Disorders
Tetracycline Compounds For Treatment Of Related Disorders
US Patent:
7807660, Oct 5, 2010
Filed:
Mar 26, 2007
Appl. No.:
11/728346
Inventors:
Stuart B. Levy - Boston MA, US
Mark L. Nelson - Norfolk MA, US
Mark L. Nelson - Norfolk MA, US
Assignee:
Trustees of Tufts College - Medford MA
International Classification:
A61K 31/65
US Classification:
514152
Abstract:
Methods and compositions for treating related disorders in a mammal are discussed. Several novel tetracycline compounds useful for treating related disorders are also included.