Inventors:
Jerald C. Sadoff - Washington DC
Steven Michael Opal - Pawtucket RI
Alan S. Cross - Washington DC
Mark William Bodmer - Oxfordshire, GB
International Classification:
A61K 39395, A61K 3940, C07K 1400
Abstract:
An antibody to tumor necrosis factor-. alpha. (anti-TNF) and an antibody to bacterial lipopolysaccharide (anti-LPS) used together in a neutropenic rat model of sepsis are shown to enhance survival of the rats relative to either antibody used alone. Pharmaceutical products including each of the components are therefore of utility in therapy of sepsis. The anti-LPS antibody included may be specific for the O-specific clain of a particular bacterial lipopolysaccharide (serotype specific antibody) but preferably recognizes the core glycolipid of lipopolysaccharide.