Inventors:
Cheppail Ramachandran - Miami FL, US
Steven J. Melnick - Miami FL, US
Assignee:
Variety Children's Hospital d/b/a Miami Children's Hospital - Miami FL
International Classification:
A61K 31/19, C07C 61/29, C07C 69/753, C07C 255/47, A61K 31/215, A61K 31/704, A61P 35/00, C12N 5/00
US Classification:
514 33, 562498, 560116, 558429, 514557, 514561, 514547, 435375
Abstract:
Amooranin (AMR) has been found to cause tumor cell death through G/M cell cycle arrest, caspase activation, and apoptosis. Furthermore, it has been demonstrated that AMR is a substrate for P-glycoprotein. Based on these activities, AMR compounds, including AMR analogs, can be used in the treatment of a number of diseases in which aberrant cellular proliferation occurs such as drug-sensitive and drug-resistant cancers, autoimmune disorders, and inflammatory diseases.