DR. STEVEN MARC PAUL, M.D.
Psychiatric at Laurelwood, Carmel, IN
License number
Indiana 0106372A
Category
Psychiatric
Type
Psychiatry
Address
Address
1145 Laurelwood, Carmel, IN 46032
Phone
(317) 285-9005
Professional information
Dr. Steven M Paul, Carmel IN - MD (Doctor of Medicine)
Specialties:
Neuropsychiatry (Psychiatry)
Address:
1145 Laurelwood, Carmel 46032
(317) 285-9005 (Phone)
(317) 285-9005 (Phone)
Certifications:
Psychiatry, 1981
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
Tulane University of Louisiana
Tulane University of Louisiana
Humanized Antibodies That Sequester Abeta Peptide
US Patent:
7195761, Mar 27, 2007
Filed:
Aug 22, 2002
Appl. No.:
10/226435
Inventors:
David M. Holtzman - St. Louis MO, US
Ronald DeMattos - Noblesville IN, US
Kelly R. Bales - Indianapolis IN, US
Steven M. Paul - Carmel IN, US
Naoya Tsurushita - Palo Alto CA, US
Maximiliano Vasquez - Palo Alto CA, US
Ronald DeMattos - Noblesville IN, US
Kelly R. Bales - Indianapolis IN, US
Steven M. Paul - Carmel IN, US
Naoya Tsurushita - Palo Alto CA, US
Maximiliano Vasquez - Palo Alto CA, US
Assignee:
Eli Lilly and Company - Indianapolis IN
Washington University - St. Louis MO
Washington University - St. Louis MO
International Classification:
C07K 16/18, A61K 39/395
US Classification:
4241331, 4241391, 5303873, 53038885
Abstract:
A method to treat conditions characterized by formation of amyloid plaques both prophylactically and therapeutically is described. The method employs humanized antibodies which sequester soluble Aβ peptide from human biological fluids or which preferably specifically bind an epitope contained within position 13–28 of the amyloid beta peptide Aβ.
Assay Method For Alzheimer's Disease
US Patent:
8444977, May 21, 2013
Filed:
Jul 12, 2010
Appl. No.:
12/834271
Inventors:
David M. Holtzman - St. Louis MO, US
Ronald DeMattos - Noblesville IN, US
Kelly R. Bales - Coatsville IN, US
David J. Cummins - Indianapolis IN, US
Steven M. Paul - Carmel IN, US
Ronald DeMattos - Noblesville IN, US
Kelly R. Bales - Coatsville IN, US
David J. Cummins - Indianapolis IN, US
Steven M. Paul - Carmel IN, US
Assignee:
Eli Lilly and Company - Indianapolis IN
Washington University - St. Louis MO
Washington University - St. Louis MO
International Classification:
A61K 39/395, A61K 49/00
US Classification:
4241391, 424 91, 4241331, 4241351, 4241521
Abstract:
A diagnostic test for preclinical and clinical Alzheimer's disease is based on plasma levels of Aβ, Aβ, their ratio, or their rate of entry following administration of antibodies that sequester Aβ. Alterations of any of these parameters from control values identifies preclinical or clinical Alzheimer's disease.
Humanized Antibodies That Sequester Amyloid Beta Peptide
US Patent:
8591894, Nov 26, 2013
Filed:
Dec 22, 2010
Appl. No.:
12/976282
Inventors:
David M Holtzman - St. Louis MO, US
Ronald DeMattos - Noblesville IN, US
Kelly R. Bales - Indianapolis IN, US
Steven M. Paul - Carmel IN, US
Naoya Tsurushita - Palo Alto CA, US
Maximiliano Vasquez - Palo Alto CA, US
Ronald DeMattos - Noblesville IN, US
Kelly R. Bales - Indianapolis IN, US
Steven M. Paul - Carmel IN, US
Naoya Tsurushita - Palo Alto CA, US
Maximiliano Vasquez - Palo Alto CA, US
Assignee:
Eli Lilly and Company - Indianapolis IN
Washington University - St. Louis MO
Washington University - St. Louis MO
International Classification:
A61K 39/395
US Classification:
4241331, 5303873, 536 2353, 435 691, 4353201, 435328
Abstract:
A method to treat conditions characterized by formation of amyloid plaques both prophylactically and therapeutically is described. The method employs humanized antibodies which sequester soluble Aβ peptide from human biological fluids or which preferably specifically bind an epitope contained within position 13-28 of the amyloid beta peptide Aβ.
Methods For Increasing Levels Of Acetylcholine
US Patent:
2001004, Nov 15, 2001
Filed:
Mar 27, 2000
Appl. No.:
09/537426
Inventors:
Henry Bryant - Indianapolis IN, US
Steven Paul - Carmel IN, US
Xin Wu - Carmel IN, US
Michele Glinn - Okemos MI, US
Steven Paul - Carmel IN, US
Xin Wu - Carmel IN, US
Michele Glinn - Okemos MI, US
International Classification:
A61K031/135
US Classification:
514/648000
Abstract:
The current invention relates to a method for increasing levels of acetylcholine in mammals comprising administering to a mammal in need thereof, an effective amount of a compound of formula I:
wherein either Ris H or a lower alkyl radical and Ris a lower alkyl radical, or Rand Rare joined together with the adjacent nitrogen atom to form a heterocyclic radical; Ris H or a lower alkyl radical; Ris H, halo, OH, a lower alkyl radical, or is a buta-1,3-dienyl radical which together with the adjacent benzene ring forms a naphthyl radical; Ris H or OH; and n is 2; or a pharmaceutically acceptable salt thereof and optionally an AChE inhibitor.
Treatment Of Central Nervous System Disorders With Selective Estrogen Receptor Modulators
US Patent:
2002001, Jan 31, 2002
Filed:
May 4, 2000
Appl. No.:
09/564966
Inventors:
Kelly Bales - Cloverdale IN, US
Henry Bryant - Indianapolis IN, US
Steven Paul - Carmel IN, US
Mary Knadler - Indianapolis IN, US
Henry Bryant - Indianapolis IN, US
Steven Paul - Carmel IN, US
Mary Knadler - Indianapolis IN, US
International Classification:
A61K031/445, A01N043/40
US Classification:
514/319000
Abstract:
The present invention provides a method of treating depression, mood swings, or Alzheimer's disease in a patient in need of such treatment by administering a selective estrogen receptor modulating compound of the formula
in which Rand Rare independently hydroxy and alkoxy of one to four carbon atoms; and Rand Rare independently methyl or ethyl, or Rand R, taken together with the nitrogen atom to which they are attached, form a pyrrolidino, methyl-pyrrolidino, dimethylpyrrolidino, piperidino, morpholino, or hexamethyleneimino ring.
Assay Method For Alzheimer's Disease
US Patent:
7771722, Aug 10, 2010
Filed:
Aug 16, 2002
Appl. No.:
10/486908
Inventors:
David M. Holtzman - St. Louis MO, US
Ronald DeMattos - Noblesville IN, US
Kelly R. Bales - Coatsville IN, US
David J. Cummins - Indianapolis IN, US
Steven M. Paul - Carmel IN, US
Ronald DeMattos - Noblesville IN, US
Kelly R. Bales - Coatsville IN, US
David J. Cummins - Indianapolis IN, US
Steven M. Paul - Carmel IN, US
Assignee:
Eli Lilly and Company - Indianapolis IN
Washington University - St. Louis MO
Washington University - St. Louis MO
International Classification:
A61K 39/395, A61K 49/00
US Classification:
4241391, 424 91, 4241331, 4241351, 4241521
Abstract:
A diagnostic test for preclinical and clinical Alzheimer's disease is based on plasma levels of Aβ, Aβ, their ratio, or their rate of entry following administration of antibodies that sequester Aβ. Alterations of any of these parameters from control values identifies preclinical or clinical Alzheimer's disease.
Humanized Antibodies That Sequester Amyloid Beta Peptide
US Patent:
7892545, Feb 22, 2011
Filed:
Feb 8, 2008
Appl. No.:
12/028641
Inventors:
David M Holtzman - St. Louis MO, US
Ronald DeMattos - Noblesville IN, US
Kelly R. Bales - Indianapolis IN, US
Steven M. Paul - Carmel IN, US
Naoya Tsurushita - Palo Alto CA, US
Maximiliano Vasquez - Palo Alto CA, US
Ronald DeMattos - Noblesville IN, US
Kelly R. Bales - Indianapolis IN, US
Steven M. Paul - Carmel IN, US
Naoya Tsurushita - Palo Alto CA, US
Maximiliano Vasquez - Palo Alto CA, US
Assignee:
Eli Lilly and Company - Indianapolis IN
Washington University - St. Louis MO
Washington University - St. Louis MO
International Classification:
A61K 39/395
US Classification:
4241331, 5303873
Abstract:
A method to treat conditions characterized by formation of amyloid plaques both prophylactically and therapeutically is described. The method employs humanized antibodies which sequester soluble Aβ peptide from human biological fluids or which preferably specifically bind an epitope contained within position 13-28 of the amyloid beta peptide Aβ.
Methods For Increasing Levels Of Acetylcholine
US Patent:
6288108, Sep 11, 2001
Filed:
Nov 14, 2000
Appl. No.:
9/700505
Inventors:
Henry Uhlman Bryant - Indianapolis IN
Michele Annette Glinn - Okemos MI
Steven Marc Paul - Carmel IN
Xin Wu - Carmel IN
Michele Annette Glinn - Okemos MI
Steven Marc Paul - Carmel IN
Xin Wu - Carmel IN
Assignee:
Eli Lilly and Company - Indianapolis IN
International Classification:
A61K 3138, A01N 4312
US Classification:
514443
Abstract:
The current invention relates to a method for increasing levels of acetylcholine comprising administering to a mammal in need thereof, an effective amount of a compound of formula (I), and optionally an AChE inhibitor. ##STR1##.
Assay Method For Alzheimer's Disease
US Patent:
2013023, Sep 5, 2013
Filed:
Apr 16, 2013
Appl. No.:
13/863629
Inventors:
David M. Holtzman - St. Louis MO, US
Ronald DeMattos - Noblesville IN, US
Kelly R. Bales - Coatsville IN, US
David J. Cummins - Indianapolis IN, US
Steven M. Paul - Carmel IN, US
Ronald DeMattos - Noblesville IN, US
Kelly R. Bales - Coatsville IN, US
David J. Cummins - Indianapolis IN, US
Steven M. Paul - Carmel IN, US
International Classification:
C07K 16/18
US Classification:
4241331, 4241721
Abstract:
A diagnostic test for preclinical and clinical Alzheimer's disease is based on plasma levels of Aβ, Aβ, their ratio, or their rate of entry following administration of antibodies that sequester Aβ. Alterations of any of these parameters from control values identifies preclinical or clinical Alzheimer's disease.