Inventors:
Leonard H. Rome - Los Angeles CA, US
Valerie A. Kickhoefer - Los Angeles CA, US
Steven M. Dubinett - Los Angeles CA, US
Sherven Sharma - Culver City CA, US
Upendra K. Kar - Dhenkanal, IN
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
International Classification:
A61K 39/00, C07H 21/04, C12N 15/63, C12N 5/00, C12N 5/02, A61P 35/00, A61K 38/00, C12N 9/96, A61K 38/54, C07K 14/52, A61P 37/02, C07K 14/00, C12N 5/071
US Classification:
4241851, 530350, 536 234, 536 231, 4353201, 435325, 435375, 435366, 4353723, 4241841, 514 193, 435188, 424 943, 530395
Abstract:
The invention relates to compositions of vault complexes containing recombinant cytokine fusion proteins that include a cytokine and a vault targeting domain, and methods of using the vault complexes to deliver the cytokines to a cell or subject, and methods for using the compositions to treat cancer, such as lung cancer.