STEVEN LEWIS ZELENKOFSKE
Physician in Center Valley, PA
License number
Pennsylvania OS005925L
Category
Osteopathic Medicine
Type
Osteopathic Physician and Surgeon
Address
Address
Center Valley, PA 18034
Personal information
See more information about STEVEN LEWIS ZELENKOFSKE at radaris.comName
Address
Phone
2225 Spyglass Hl, Center Valley, PA 18034
2225 Spyglass Hl, Center Valley, PA 18034
3340 Hamilton St, Allentown, PA 18103
1250 Cedar Crest Blvd, Allentown, PA 18103
Professional information
Use Of Renin Inhibitors In Therapy
US Patent:
2008016, Jul 3, 2008
Filed:
Mar 16, 2005
Appl. No.:
10/592973
Inventors:
David Louis Feldman - Teaneck NJ, US
Steven Zelenkofske - Center Valley PA, US
Michaela Dinboeck - Basel, CH
Margaret Forney Prescott - Morris Plains NJ, US
Steven Zelenkofske - Center Valley PA, US
Michaela Dinboeck - Basel, CH
Margaret Forney Prescott - Morris Plains NJ, US
International Classification:
A61K 31/496, A61K 31/165, A61P 3/10, A61P 9/12, A61P 9/00, A61P 3/00
US Classification:
51425218, 514616
Abstract:
The present is directed to a method for the prevention of, delay progression to or treatment of a condition or disease selected from diabetes type 2 (associated with or without hypertension), severe hypertension, PH, malignant hypertension, isolated systolic hypertension, familial dyslipidemic hypertension, endothelial dysfunction (with or without hypertension), survival post-MI, increase of formation of collagen and other extracellular matrix proteins, restenosis after stenting, PVD including PAD and peripheral venous disorders, CAD, morbidity, mortality, cerebrovascular diseases, metabolic disorder (Syndrome X), AF, renoprotection, reduction of proteinuria, renal failure, glomerulonephritis, nephrotic syndrome, renal fibrosis, AIN, ATN, acute tubulo-interstitial nephritis, PKD, vascular inflammation, rennin secreting tumors, vasculitides or closure, restenosis of dialysis access grafts comprising administering a compound of formula (I) or a pharmaceutically acceptable salt thereof alone or in combination with another active ingredient.
Nucleic Acid Modulators Of Glycoprotein Vi
US Patent:
8318923, Nov 27, 2012
Filed:
Jun 3, 2010
Appl. No.:
12/793572
Inventors:
Juliana M. Layzer - Durham NC, US
Christopher P. Rusconi - Durham NC, US
Douglas Brooks - Durham NC, US
Steven L. Zelenkofske - Center Valley PA, US
Christopher P. Rusconi - Durham NC, US
Douglas Brooks - Durham NC, US
Steven L. Zelenkofske - Center Valley PA, US
Assignee:
Regado Biosciences, Inc. - Durham NC
International Classification:
C07H 21/04
US Classification:
536 245
Abstract:
The present invention relates, in general, to a pharmacologic system to modulate the biology of platelets based upon a nucleic acid ligand that can interact with and modulate the activity of platelet glycoprotein GPVI to regulate platelet function. These nucleic acid ligands are also actively reversible using a modulator that inhibits the activity of the nucleic acid ligand to neutralize this pharmacologic effect and thereby restore GPVI function, including collagen binding, platelet adhesion, collagen-induced platelet activation, and collagen-induced platelet aggregation. The invention further relates to compositions comprising the nucleic acid ligand, the ligand and a modulator, methods to generate the nucleic acid ligand and its modulator, as well as methods of using these agents and compositions in medical therapeutic and diagnostic procedures.