Inventors:
Raymond L. Houghton - Seattle WA, US
Steven G. Reed - Seattle WA, US
Syamal Raychaudhuri - Seattle WA, US
Assignee:
InBios International, Inc. - Seattle WA
International Classification:
G01N 33/53, G01N 33/542, G01N 33/00, A61K 39/00, C07K 1/00, C07K 14/00, C07K 17/00
US Classification:
435 794, 435 79, 435 792, 435 71, 4241841, 4241851, 4242651, 4242691, 530350
Abstract:
The present invention provides rapid diagnostic assays for the detection of which can readily be used in the field, leading to more rapid treatment. In certain embodiments, the inventive assays, including ELISA and lateral flow assays, employ antibodies that may be effectively employed to detect the antigen TSA, which is present in both promastigotes grown in culture and in amastigotes. Such assays may be employed to detect the presence of cutaneous leishmaniasis in a subject using scrapings, biopsies, and/or aspirates taken from cutaneous lesions.