Inventors:
Steven G. Reed - Bellevue WA, US
Jiangchun Xu - Bellevue WA, US
Davin C. Dillon - Issaquah WA, US
Marc W. Retter - Carnation WA, US
Susan L. Harlocker - Seattle WA, US
Assignee:
CORIXA CORPORATION - Hamilton MT
International Classification:
A61K 39/00, C07K 2/00, C07H 21/04, A61P 35/00, G01N 33/68, C12N 5/0783, A61K 35/12, A61P 37/04
US Classification:
4241921, 530300, 536 231, 436 64, 435375, 435325, 424 9371, 4241841
Abstract:
Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.