Inventors:
Laurence Turka - Merion Station PA, US
Steven Bensinger - Los Angeles CA, US
Patrick Walsh - Philadelphia PA, US
International Classification:
A61K 48/00, C07H 21/02, C12N 5/08, A61K 9/127, C12N 15/88
US Classification:
424093210, 435372000, 435458000, 424450000, 536023100
Abstract:
The present invention relates to compositions and methods for modulating the expression and/or activity of PTEN in T cells, regulatory T cells, and CD4 T cells. The manipulation of PTEN provides a means for regulating an immune response.