Inventors:
Robert W. Henkens - Beaufort NC, US
John P. O'Daly - Carrbor NC, US
Marek Wojciechowski - Cary NC, US
Honghua Zhang - San Diego CA, US
Najih Naser - Orlando FL, US
R. Michael Roe - Apex NC, US
Thomas N. Stewart - Durham NC, US
Deborah M. Thompson - Raleigh NC, US
Rebecca Sundseth - Durham NC, US
Steven E. Wegner - Chapel Hill NC, US
International Classification:
G01N 15/06, G01N 21/76, G01N 21/00, B32B 5/02, C07H 21/00, C12Q 1/68
US Classification:
422 681, 435 6, 422 52, 422 55, 422 821, 422 61, 536 231
Abstract:
An electrochemical detection system which specifically detects selected nucleic acid segments is described. The system utilizes biological probes such as nucleic acid or peptide nucleic acid probes which are complementary to and specifically hybridize with selected nucleic acid segments in order to generate a measurable current when an amperometric potential is applied. The electrochemical signal can be quantified.