Inventors:
Richard P. Phipps - Pittsford NY, US
Naxin Guo - Rochester NY, US
Steven Feldon - Rochester NY, US
Assignee:
UNIVERSITY OF ROCHESTER - Rochester NY
International Classification:
A61K 38/18, A61K 9/00, A61K 31/201, A61K 38/00, A61K 31/166, A61K 38/17, A61P 27/02, A61K 31/713, A61K 31/4439, B82Y 5/00
US Classification:
424400, 514 44 A, 514559, 514342, 514 206, 514619, 514 89, 514 208, 977700, 977906
Abstract:
The present invention relates to a methods and compositions for the treatment of and management of symptoms for thyroid eye disease. The methods include administering to a patient having thyroid eye disease an agent that interferes with hyaluronan synthesis in an amount that is effective to inhibit hyaluronan synthesis in a retro-ocular space. The pharmaceutical compositions hat includes a carrier suitable for ophthalmic delivery and an agent that interferes with hyaluronan synthesis. Combination therapies are also disclosed.