Inventors:
Anthony J. Piraino - Media PA
Steven D. Saris - Ardmore PA
Assignee:
Ciba-Geigy Corporation - Ardsley NY
International Classification:
A61K 31415, A61K 3140, A61K 3134, A61K 31335, A61K 31265, A61K 3118, A61K 31135, A61K 31095, A61K 3110, A61K 31075, A61K 31045, A61K 3105, A61K 3144
Abstract:
A method of reducing serum uric acid and/or increasing renal clearance of uric acid in a mammal in need thereof comprising administering to such mammal a uricosuric effective amount of a thromboxane synthetase inhibitor, a thromboxane receptor antagonist, or both in a combined uricosuric effective amount is disclosed. Compositions having one or more of the foregoing in combination with one or more known uricosurics are also set forth.