Inventors:
Steven D. Chessler - San Diego CA, US
Arthur T. Suckow - San Diego CA, US
Assignee:
The Regents of the University of California - Oakland CA
International Classification:
A61K 39/395, A61K 38/02, A61K 31/7052, G01N 33/53, C12Q 1/68, G01N 33/68, A61P 1/18, A61P 3/10, A61P 35/00
US Classification:
4241721, 514 2, 514 44, 435 72, 435 721, 435 6, 436 86
Abstract:
The role of synaptic adhesion molecules in human cell development and function is largely unknown. This invention provides methods to study β-cell function in native tissue through the use of novel adhesion and migrations assays. Through the use of these assays, the inventors have been able to for the first time describe the contribution of SAMs to human β-cell adhesion, spreading, and motility. Furthermore, the inventors have used the results of these assays to develop methods for detection, treatment, and prevention of diseases related to the pancreas.