STEVEN BREM
Medical Practice in Haverford, PA
License number
Pennsylvania MD444179
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Haverford, PA 19041
Personal information
See more information about STEVEN BREM at radaris.comName
Address
Phone
130 Booth Ln, Haverford, PA 19041
Professional information
Methods Of Predicting High Grade Gliomas Using Senescence Associated Genes
US Patent:
2012032, Dec 20, 2012
Filed:
Aug 29, 2012
Appl. No.:
13/597753
Inventors:
Domenico Coppola - Tampa FL, US
Steven Brem - Haverford PA, US
Steven Brem - Haverford PA, US
Assignee:
H. Lee Moffitt Cancer Center and Research Institute, Inc. - Tampa FL
International Classification:
C40B 30/04, C12Q 1/68, G01N 33/574
US Classification:
506 9, 435 71, 435375, 435 612, 435 611, 435 613
Abstract:
The present invention relates to biomarkers for neoplasias such as high grade gliomas. The inventors have discovered that the overexpression of senescence associated genes (SAG) is associated with a poor prognosis in subjects with high grade gliomas. The present invention provides SAG biomarkers for predicting response to therapy for subjects having high grade glioma based on dividing the samples into high and low risk groups; diagnosing high grade glioma; monitoring progression of high grade glioma from one biological state to another; and determining efficacy of treatment for high grade gliomas.