Inventors:
Steve H. Nguyen - Oakland CA, US
Sergio Pichuantes - El Cerrito CA, US
Assignee:
Novartis Vaccines and Diagnostics, Inc. - Emeryville CA
International Classification:
A61K 49/00, A61K 39/38, A61K 39/295, A61K 39/12, C12Q 1/00, C12Q 1/70, G01N 33/53, G01N 33/542, G01N 33/00, G01N 33/543, A61K 39/285
US Classification:
4242021, 424 91, 4241841, 4242041, 435 4, 435 5, 435 71, 435 79, 435 792, 436518
Abstract:
Novel methods and immunodiagnostic test kits for the detection of hantavirus infection are disclosed. The methods and kits employ combinations of recombinant N and/or G1 antigens from at least six different hantavirus serotypes, including Hantaan (HTNV), Puumala (PUUV), Seoul (SEOV), Dobrava (DOBV), Sin Nombre (SNV) and Andes (ANDV). Additional hantavirus antigens from these and other hantavirus types may also be present. The methods provide for highly accurate results and allow the detection of infection so that treatment can be administered and death avoided.