Inventors:
Jia Guo - Pittsford NY, US
Xin Lin - Rochester NY, US
Steve Georas - Rochester NY, US
Patricia Sime - Pittsford NY, US
Assignee:
UNIVERSITY OF ROCHESTER - Rochester NY
International Classification:
A61K 38/44, A61P 19/04, A61K 49/00, C12Q 1/68, G01N 33/567
US Classification:
424 944, 435 612, 435 61, 435 721, 800 3
Abstract:
The present invention is directed to methods of diagnosing and treating a fibrotic condition in a mammalian subject. These methods involve measuring the levels of trimethylation at lysine residue 27 of histone-3 and/or measuring the expression levels of EZH2 or YY-1. Agents useful for treating fibrosis or a fibrotic condition are also disclosed.