Inventors:
Stephen Waters - Branford CT, US
James Krause - Madison CT, US
International Classification:
C07K 14/705, C07H 21/04, C12P 21/06
US Classification:
435069100, 435320100, 435325000, 536023500, 530350000
Abstract:
Chimeric H3 receptor polypeptides are provided, as are polynucleotides encoding such polypeptides, and vectors and cells for recombinant expression of such polypeptides. Chimeric H3 receptor polynucleotides and polypeptides may be used, for example, to identify agents that specifically interact with H3 receptor. Such agents find use within therapies for humans and animals afflicted with conditions responsive to histamine H3 receptor modulation.