STEPHEN W SMITH
Engineering in Newton, MA

6355198, Mar 12, 2002

Jan 8, 1998

09/004583

Enoch Kim - Boston MA
Younan Xia - Seattle WA
Milan Mrksich - Chicago IL
Rebecca J. Jackman - Boston MA
Xiao-Mei Zhao - Shaker Heights OH
Stephen P. Smith - Newton MA
Mara G. Prentiss - Cambridge MA
George M. Whitesides - Newtown MA
Christian Marzolin - Paris, FR

President and Fellows of Harvard College - Cambridge MA

B29C 3910

264259, 264299, 264330

Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or nonplanar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface. Waveguide arrays, combinatorial chemical or biochemical libraris, etc.

6752942, Jun 22, 2004

Oct 30, 2001

10/016614

Enoch Kim - Boston MA
Younan Xia - Seattle WA
Milan Mrksich - Chicago IL
Rebecca J. Jackman - Boston MA
Xiao-Mei Zhao - Shaker Heights OH
Stephen P. Smith - Newton MA
Mara G. Prentiss - Cambridge MA
George M. Whitesides - Newton MA
Christian Marzolin - Paris, FR

President and Fellows of Harvard College - Cambridge MA

B29C 4102

264112, 264259, 264299, 264330

Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or non-planar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface. Waveguide arrays, combinatorial chemical or biochemical libraries, etc.

6660192, Dec 9, 2003

Aug 9, 2000

09/634201

Enoch Kim - Boston MA 02116
Younan Xia - Seattle WA 98115
Milan Mrksich - Chicago IL 60601
Rebecca J. Jackman - Boston MA 02114
Xiao-Mei Zhao - Shaker Heights OH 44120
Stephen P. Smith - Newton MA 02458
Mara G. Prentiss - Cambridge MA 02138
George M. Whitesides - Newton MA 02158
Christian Marzolin - Paris, FR

B29D 1100

264 127, 264496, 264621, 264260

Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or non-planar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface. Waveguide arrays, combinatorial chemical or biochemical libraris, etc.

2004017, Sep 16, 2004

Oct 1, 2003

10/677103

Enoch Kim - Boston MA, US
Younan Xia - Seattle WA, US
Milan Mrksich - Chicago IL, US
Rebecca Jackman - Boston MA, US
Xiao-Mei Zhao - Shaker Heights OH, US
Stephen Smith - Newton MA, US
Mara Prentiss - Cambridge MA, US
George Whitesides - Newton MA, US
Christian Marzolin - Paris, FR

President and Fellows of Harvard College - Cambridge MA

B29D011/00

264/001270, 264/001280

Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or non-planar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface. Waveguide arrays, combinatorial chemical or biochemical libraris, etc. can be made. Differences in refractive index of waveguide and cladding can be created by subjecting the waveguide and cladding, made of indentical prepolymeric material, to different polymerization or cross-linking conditions. Interferometers are defined by coupling arrays of waveguides, where coupling can be controlled by altering the difference in refractive index between cladding and waveguide at any desired location of the array. Alteration and refractive index can be created photochemically, chemically, or the like. Sensors also are disclosed, including biochemical sensors.