STEPHEN T HOFFMAN
Engineers in Gaithersburg, MD
License number
Pennsylvania PE029415E
Category
Engineers
Type
Professional Engineer
Address
Address
2
Gaithersburg, MD 20879
Pennsylvania
Pennsylvania
Professional information
Apparatuses And Methods For The Production Of Haematophagous Organisms And Parasites Suitable For Vaccine Production
US Patent:
2007016, Jul 19, 2007
Filed:
Mar 21, 2007
Appl. No.:
11/726622
Inventors:
Stephen Hoffman - Gaithersburg MD, US
Thomas Luke - Brookville MD, US
Thomas Luke - Brookville MD, US
International Classification:
A01K 67/033, C12N 1/10
US Classification:
800013000, 435258100
Abstract:
Disclosed are apparatuses and methods for the production of attenuated aseptic parasites in haematophagous insects generally, and production of species sporozoites in species mosquitoes specifically; apparatuses and methods for the production of strains of haematophagous insects with desired properties such as hypoallergenicity or hyperinfectivity; methods of producing a parasite strain that is capable of withstanding cyropreservation at temperatures close to freezing; apparatuses and methods for the injection of an attenuated parasite vaccine; production of parasites and haematophagous insects that are free from contamination by unwanted biological agents; apparatuses for the reconstruction of complex parasitic life cycles aseptically to avoid the contamination of the parasite or the insect vector host with unwanted biological agents.
Protective Four Amino Acid Epitope Against Plasmodium Vivax Malaria
US Patent:
5095093, Mar 10, 1992
Filed:
Nov 6, 1990
Appl. No.:
7/609551
Inventors:
Stephen L. Hoffman - Gaithersburg MD
Yupin Charoenvit - Silver Spring MD
Trevor R. Jones - Brooklyn CT
Yupin Charoenvit - Silver Spring MD
Trevor R. Jones - Brooklyn CT
Assignee:
The United States of America as represented by the Secretary of the Navy - Washington DC
International Classification:
A61K 3700
US Classification:
530330
Abstract:
A synthetic peptide of the human malaria Plasmodium vivax, containing at st one repeat of a synthetic peptide having the amino acid sequence Ala-Gly-Asp-Arg (AGDR) which is a protective epitope found on the circumsporozoite (CS) protein of the sporozoites of the human maleria Plasmodium vivax. When a monoclonal antibody specific for this four amino acid sequence binds to the CS protein of the P. vivax sporozoite in vivo, infection is prevented. Also described are pharmaceutical formulations of these peptides.
Purified Plasmodium And Vaccine Compositions
US Patent:
8367810, Feb 5, 2013
Filed:
Aug 27, 2010
Appl. No.:
12/870102
Inventors:
B. Kim Lee Sim - Gaithersburg MD, US
Minglin Li - Ellicott City MD, US
Richard E. Stafford - Annandale VA, US
Stephen L. Hoffman - Gaithersburg MD, US
Minglin Li - Ellicott City MD, US
Richard E. Stafford - Annandale VA, US
Stephen L. Hoffman - Gaithersburg MD, US
Assignee:
Sanaria Inc. - Rockville MD
International Classification:
A23J 1/00
US Classification:
530413, 530414, 4242691, 4242721
Abstract:
Disclosed are substantially purified sporozoites and preparations of sporozoites substantially separated from attendant non-sporozoite material, where the preparations of sporozoites have increasing levels of purity. Vaccines and pharmaceutical compositions comprising purified sporozoites are likewise provided. Methods of purifying preparations of Plasmodium sporozoites are also provided.
Purified Plasmodium And Vaccine Composition
US Patent:
2013025, Sep 26, 2013
Filed:
Dec 28, 2012
Appl. No.:
13/730281
Inventors:
Minglin Li - Ellicott City MD, US
Richard E. Stafford - Annandale VA, US
Stephen L. Hoffman - Gaithersburg MD, US
Richard E. Stafford - Annandale VA, US
Stephen L. Hoffman - Gaithersburg MD, US
Assignee:
Sanaria Inc. - Rockville MD
International Classification:
A61K 39/015
US Classification:
4242721
Abstract:
Disclosed are substantially purified sporozoites and preparations of sporozoites substantially separated from attendant non-sporozoite material, where the preparations of sporozoites have increasing levels of purity. Vaccines and pharmaceutical compositions comprising purified sporozoites are likewise provided. Methods of purifying preparations of sporozoites are also provided.
Methods For Vaccinating Against Malaria
US Patent:
8232255, Jul 31, 2012
Filed:
Oct 22, 2003
Appl. No.:
10/532081
Inventors:
Stephen L. Hoffman - Gaithersburg MD, US
Ruobing Wang - Potomac MD, US
Judith E. Epstein - Kensington MD, US
Joseph D. Cohen - Brussels, BE
Ruobing Wang - Potomac MD, US
Judith E. Epstein - Kensington MD, US
Joseph D. Cohen - Brussels, BE
Assignee:
GlaxoSmithKline Biologicals S.A. - Rixensart
The United States of America as represented by the Secretary of the Navy - Washington DC
The United States of America as represented by the Secretary of the Navy - Washington DC
International Classification:
A61K 39/00, A61K 48/00
US Classification:
514 44R, 4241841
Abstract:
The invention pertains to methods for protecting against malaria infection by vaccination. The method of the invention involves priming an anti-malaria immune response with a DNA-based vaccine and boosting that response with a protein-based a vaccine. The method of the invention also relates to broadening the resulting immune response by boosting with a protein-based vaccine.
Methods For The Prevention Of Malaria
US Patent:
2005022, Oct 6, 2005
Filed:
May 20, 2005
Appl. No.:
11/133963
Inventors:
Stephen Hoffman - Gaithersburg MD, US
Thomas Luke - Brookville MD, US
Thomas Luke - Brookville MD, US
International Classification:
A61K039/015
US Classification:
424272100
Abstract:
The invention comprises novel compositions and methods for protecting subjects against malaria. The compositions of the invention include aseptic, live attenuated sporozoites, and the methods include the inoculation of subjects with these compositions by means of parenteral, non-intravenous inoculation, in particular, but not limited to subcutaneous, intramuscular, intradermal, mucosal, submucosal, and cutaneous administration.
Purified Plasmodium And Vaccine Composition
US Patent:
2013022, Aug 29, 2013
Filed:
Dec 28, 2012
Appl. No.:
13/730294
Inventors:
Sanaria Inc. - , US
Minglin Li - Ellicott City MD, US
Richard E. Stafford - Annandale VA, US
Stephen L. Hoffman - Gaithersburg MD, US
Minglin Li - Ellicott City MD, US
Richard E. Stafford - Annandale VA, US
Stephen L. Hoffman - Gaithersburg MD, US
Assignee:
Sanaria Inc. - Rockville MD
International Classification:
A61K 39/015, A61K 31/4706
US Classification:
4242721
Abstract:
Disclosed are substantially purified sporozoites and preparations of sporozoites substantially separated from attendant non-sporozoite material, where the preparations of sporozoites have increasing levels of purity. Vaccines and pharmaceutical compositions comprising purified sporozoites are likewise provided. Methods of purifying preparations of sporozoites are also provided.
Immunogenic Four Amino Acid Epitope Against Plasmodium Vivax
US Patent:
5599543, Feb 4, 1997
Filed:
Mar 9, 1992
Appl. No.:
7/848636
Inventors:
Stephen L. Hoffman - Gaithersburg MD
Yupin Charoenvit - Silver Spring MD
Trevor R. Jones - Brooklyn CT
Yupin Charoenvit - Silver Spring MD
Trevor R. Jones - Brooklyn CT
Assignee:
The United States of America as represented by the Secretary of the Navy - Washington DC
International Classification:
A61K 39015
US Classification:
4241911
Abstract:
An agent and pharmaceutical formulations of the agent containing a synthetic peptide of the human malaria Plasmodium vivax, containing at least one repeat of a synthetic peptide having the amino acid sequence Ala-Gly-Asp-Arg (AGDR) which is a protective epitope found on the circumsporozoite (CS) protein of the sporozoites of the human malaria Plasmodium vivax. When a monoclonal antibody specific for this four amino acid sequence binds to the CS protein of the P. vivax sporozoite in vivo, infection is prevented.
Pharmaceutical Compositions Comprising Attenuated Plasmodium Sporozoites And Glycolipid Adjuvants
US Patent:
2012028, Nov 15, 2012
Filed:
May 11, 2012
Appl. No.:
13/470128
Inventors:
Sumana CHAKRAVARTY - Derwood MD, US
Stephen L. HOFFMAN - Gaithersburg MD, US
Moriya TSUJI - New York NY, US
Stephen L. HOFFMAN - Gaithersburg MD, US
Moriya TSUJI - New York NY, US
International Classification:
A61K 39/015, A61P 33/06
US Classification:
4242721
Abstract:
Disclosed herein are pharmaceutical compositions comprising sporozoite-stage parasites and compatible glycolipid adjuvants useful in vaccines for preventing or reducing the risk of malaria. In particular, human host range and analogues of α-galactosylceramide (α-GalCer), a ligand for natural killer T (NKT) cells, are combined in pharmaceutical compositions, which are useful as vaccines against malaria. Methods of use are also provided.
Methods For The Prevention Of Malaria
US Patent:
2005020, Sep 22, 2005
Filed:
Apr 22, 2005
Appl. No.:
11/112358
Inventors:
Stephen Hoffman - Gaithersburg MD, US
Thomas Luke - Brookville MD, US
Thomas Luke - Brookville MD, US
International Classification:
A61K039/015
US Classification:
424272100
Abstract:
The invention comprises a novel method for protecting subjects against malaria. The method of the invention involves inoculation with attenuated sporozoites, and in particular, but not limited to subcutaneous, intramuscular, intradermal, mucosal, submucosal, and cutaneous administration.