STEPHEN R HILL
Plumbers in Boxford, MA
License number
Massachusetts 27190
Issued Date
Apr 15, 2005
Expiration Date
May 1, 2018
Type
Journeyman Plumber
Address
Address
Boxford, MA 01921
Professional information
Methods Of Protecting Against Radiation Injury
US Patent:
7649013, Jan 19, 2010
Filed:
Nov 24, 2004
Appl. No.:
10/995565
Inventors:
Chiang J. Li - West Roxbury MA, US
Stephen A. Hill - Boxford MA, US
YouZhi Li - Westwood MA, US
Stephen A. Hill - Boxford MA, US
YouZhi Li - Westwood MA, US
Assignee:
ArQule, Inc. - Woburn MA
International Classification:
A61K 31/355, A61K 31/12, A61K 31/35
US Classification:
514455, 514680, 514454
Abstract:
Administration of a modulator of cell cycle checkpoint activation, which is preferably β-lapachone, or a pharmaceutically acceptable salt, prodrug, metabolite, analog or derivative thereof, protects normal cells against radiation injury. The invention includes methods of preventing radiation damage. The invention also provides methods for treating conditions such as cancer with radiotherapy, by administering a modulator of cell cycle checkpoint activation to a subject, prior to administration of radiotherapy.