Inventors:
Brij M. Moudgil - Gainesville FL, US
Glenn A. Walter - Newberry FL, US
Stephen R. Grobmyer - Shaker Heights OH, US
Swadeshmukul Santra - Orlando FL, US
Huabei Jiang - Gainesville FL, US
Scott Chang Brown - Hockessin DE, US
Edward W. Scott - Gainesville FL, US
Qizhi Zhang - Gainesville FL, US
Niclas Bengtsson - Lake Forest Park WA, US
Assignee:
University of Florida Research Foundation, Inc. - Gainesville FL
International Classification:
A61K 49/04, A61K 49/00, A61B 5/055, A61N 5/00
US Classification:
424 942, 424 92, 424 932, 424 96, 600411, 600431
Abstract:
Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging.