Inventors:
Dale L. Ludwig - Randolph NJ, US
Stephen R. Plymate - Des Moines WA, US
Assignee:
ImClone Systems Incorporated - New York NY
University of Washington - Seattle WA
International Classification:
A61K 39/395, A61P 35/00, A61K 31/337, A61K 31/704, C12N 15/13, C12N 15/63, C12N 5/10, C12N 1/19
US Classification:
4241331, 4241301, 4241361, 514449, 514 34, 4241781, 536 2353, 4353201, 435325, 435358, 435365, 4353721, 4352542
Abstract:
The invention provides methods of treating bone cancer, particularly metastatic bone cancer, by administering an IGF-IR antagonist and/or a PDGFRα antagonist. The invention also provides antibodies that bind to human PDGFRα and neutralize activation of the receptor. The invention further provides a methods for neutralizing activation of PDGFRα, and a methods of treating a mammal with a neoplastic disease using the antibodie alone or in combination with other agents.