STEPHEN PAUL HALE
Pilots at Brookside Ave, Belmont, MA
License number
Massachusetts A5290413
Issued Date
Feb 2016
Expiration Date
Feb 2018
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
133 Brookside Ave, Belmont, MA 02478
Personal information
See more information about STEPHEN PAUL HALE at radaris.comName
Address
Phone
38 Railroad Ave #2, Gloucester, MA 01930
900 Governors Dr APT 29, Winthrop, MA 02152
PO Box 190295, Boston, MA 02119
70 High Street Ext, Natick, MA 01760
176 Hubbard St, Ludlow, MA 01056
Professional information
Methods For Synthesis Of Encoded Libraries
US Patent:
7972994, Jul 5, 2011
Filed:
Jun 9, 2006
Appl. No.:
11/450938
Inventors:
Barry Morgan - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Cambridge MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Auburn MA, US
Paulo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Cambridge MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Auburn MA, US
Paulo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US
Assignee:
GlaxoSmithKline LLC - Philadelphia PA
International Classification:
C40B 50/16
US Classification:
506 31, 506 7, 506 13, 506 23, 506 25, 506 30, 435 6, 435 912, 536 231, 530300, 530350
Abstract:
The present invention provides methods of synthesizing libraries of molecules comprising a functional moiety which is operatively linked to an encoding oligonucleotide, wherein the encoding oligonucleotide comprises a capping sequence containing degenerate nucleotides. The methods generally include providing a solution comprising initiator compounds comprising an initial functional moiety comprising n building blocks which is operatively linked to an initial oligonucleotide; dividing the solution into reaction vessels; reacting the initiator compounds in each reaction vessel with a building block comprising a complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide in each aliquot with a distinct incoming oligonucleotide in the presence of an enzyme which catalyzes the ligation of the incoming oligonucleotide and the initial oligonucleotide, under conditions suitable for enzymatic ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide.
Methods For Synthesis Of Encoded Libraries
US Patent:
7972992, Jul 5, 2011
Filed:
Dec 17, 2004
Appl. No.:
11/015458
Inventors:
Barry Morgan - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Cambridge MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - San Francisco CA, US
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Auburn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Cambridge MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - San Francisco CA, US
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Auburn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US
Assignee:
Praecis Pharmaceuticals, Inc. - Waltham MA
International Classification:
C40B 50/00
US Classification:
506 23, 506 7, 506 13, 435 6
Abstract:
The present invention provides methods of synthesizing a molecule comprising a functional moiety which is operatively linked to an encoding oligonucleotide. The methods include providing an initiator compound comprising an initial functional moiety comprising n building blocks, wherein the initial functional moiety comprises at least one reactive group, and is operatively linked to an initial oligonucleotide; reacting the initiator compound with a building block comprising at least one complementary reactive group, under conditions suitable for reaction of the complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide with an incoming oligonucleotide corresponding to the building block in the presence of an enzyme which catalyzes ligation of the initial oligonucleotide and the incoming oligonucleotide, under conditions suitable for ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide.
Methods For Synthesis Of Encoded Libraries
US Patent:
7935658, May 3, 2011
Filed:
Oct 4, 2007
Appl. No.:
11/906939
Inventors:
Barry Morgan - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Bedford MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen, DK
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Lynn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Bedford MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen, DK
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Lynn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US
Assignee:
Praecis Pharmaceuticals, Inc. - Waltham MA
International Classification:
C40B 30/10
US Classification:
506 12, 506 7, 506 13, 506 23, 435 6, 435 5, 435 912, 536 231, 536 242
Abstract:
The present invention provides methods of synthesizing libraries of molecules comprising a functional moiety which is operatively linked to an encoding oligonucleotide. The methods generally include providing a solution comprising initiator compounds comprising an initial functional moiety which comprises n building blocks which comprise at least one reactive group, which is operatively linked to an initial oligonucleotide; dividing the solution into reaction vessels; reacting the initiator compounds in each reaction vessel with a building block comprising a complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide in each aliquot with a distinct incoming oligonucleotide in the presence of an enzyme which catalyzes the ligation of the incoming oligonucleotide and the initial oligonucleotide, under conditions suitable for enzymatic ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide which identifies the structure of the functional moiety.
Macrocyclic Compounds For Inhibition Of Tumor Necrosis Factor Alpha
US Patent:
8338565, Dec 25, 2012
Filed:
Aug 20, 2009
Appl. No.:
12/544604
Inventors:
Jinbo Lee - Andover MA, US
Julian F. Bond - Weymouth MA, US
Nicholas Terrett - Sherborn MA, US
Daniel Wang - Duxbury MA, US
Timothy F. Briggs - Cambridge MA, US
Benjamin Adam Seigal - Watertown MA, US
Wei-Chuan Sun - Menlo Park CA, US
Stephen P. Hale - Belmont MA, US
Julian F. Bond - Weymouth MA, US
Nicholas Terrett - Sherborn MA, US
Daniel Wang - Duxbury MA, US
Timothy F. Briggs - Cambridge MA, US
Benjamin Adam Seigal - Watertown MA, US
Wei-Chuan Sun - Menlo Park CA, US
Stephen P. Hale - Belmont MA, US
Assignee:
Ensemble Therapeutics Corporation - Cambridge MA
International Classification:
C07K 11/02, A61K 38/12
US Classification:
530317, 514 211
Abstract:
Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.
Methods For Identifying Compounds Of Interest Using Encoded Libraries
US Patent:
7989395, Aug 2, 2011
Filed:
Oct 23, 2006
Appl. No.:
11/584880
Inventors:
Barry Morgan - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Bedford MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Lynn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Bedford MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Lynn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US
Assignee:
GlaxoSmithKline LLC - Philadelphia PA
International Classification:
C40B 50/16
US Classification:
506 31, 506 23, 506 16, 506 5, 435 6, 435 912, 536 231, 536 242
Abstract:
The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.
Methods For Identifying Compounds Of Interest Using Encoded Libraries
US Patent:
2012007, Mar 22, 2012
Filed:
Mar 18, 2011
Appl. No.:
13/051350
Inventors:
Barry Morgan - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Cambridge MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Auburn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Cambridge MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Auburn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US
Assignee:
GlaxoSmithKline LLC - Philadelphia PA
International Classification:
C40B 20/04
US Classification:
506 4
Abstract:
The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.
Methods For Synthesis Of Encoded Libraries
US Patent:
8410028, Apr 2, 2013
Filed:
Mar 18, 2011
Appl. No.:
13/051314
Inventors:
Barry Morgan - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Cambridge MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Fairfax VA, US
Steffan Phillip Creaser - Cambridge MA, US
George J. Franklin - Auburn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford WA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Cambridge MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Fairfax VA, US
Steffan Phillip Creaser - Cambridge MA, US
George J. Franklin - Auburn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford WA, US
Assignee:
GlaxoSmithKline LLC - Philadelphia PA
International Classification:
C40B 50/08, C40B 50/06, C40B 50/10
US Classification:
506 27, 506 26, 506 28
Abstract:
The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
Methods For Synthesis Of Encoded Libraries
US Patent:
2011013, Jun 9, 2011
Filed:
Feb 9, 2011
Appl. No.:
13/023599
Inventors:
Barry MORGAN - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Bedford MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Lynn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Bedford MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Burlington MA, US
Steffen Phillip Creaser - Cambridge MA, US
George J. Franklin - Lynn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US
Assignee:
Praecis Pharmaceuticals Incorporated - Waltham MA
International Classification:
C40B 50/06
US Classification:
506 26
Abstract:
The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
Methods For Synthesis Of Encoded Libraries
US Patent:
8598089, Dec 3, 2013
Filed:
Mar 4, 2011
Appl. No.:
13/040674
Inventors:
Barry Morgan - Franklin MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Cambridge MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Fairfax VA, US
Steffan Phillip Creaser - Cambridge MA, US
George J. Franklin - Auburn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US
Stephen Hale - Belmont MA, US
Christopher C. Arico-Muendel - West Roxbury MA, US
Matthew Clark - Cambridge MA, US
Richard Wagner - Cambridge MA, US
David I. Israel - Concord MA, US
Malcolm L. Gefter - Lincoln MA, US
Dennis Benjamin - Redmond WA, US
Nils Jakob Vest Hansen - Copenhagen V, DK
Malcolm J. Kavarana - Fairfax VA, US
Steffan Phillip Creaser - Cambridge MA, US
George J. Franklin - Auburn MA, US
Paolo A. Centrella - Acton MA, US
Raksha A. Acharya - Bedford MA, US
Assignee:
GlaxoSmithKline LLC - Philadelphia PA
International Classification:
C40B 40/06, C12P 19/34
US Classification:
506 16, 536 221, 536 243
Abstract:
The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.